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Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition
- Issue Date
- 9월-2020
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- Orodispersible film; Low molecular hyaluronic acid; Carboxymethyl cellulose; Disintegration time; Mechanical properties
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.29, no.9, pp.1233 - 1239
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 29
- Number
- 9
- Start Page
- 1233
- End Page
- 1239
- ISSN
- 1226-7708
- Abstract
- Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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