Maackiain, a compound derived fromSophora flavescens, increases IL-1 beta production by amplifying nigericin-mediated inflammasome activation
DC Field | Value | Language |
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dc.contributor.author | Huh, Jin-Won | - |
dc.contributor.author | Lee, Jung-Hoon | - |
dc.contributor.author | Jeon, Eekhyoung | - |
dc.contributor.author | Ryu, Hyung Won | - |
dc.contributor.author | Oh, Sei-Ryang | - |
dc.contributor.author | Ahn, Kyung-Seop | - |
dc.contributor.author | Jun, Hyun Sik | - |
dc.contributor.author | Ha, Un-Hwan | - |
dc.date.accessioned | 2021-08-30T18:45:21Z | - |
dc.date.available | 2021-08-30T18:45:21Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 2211-5463 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/54274 | - |
dc.description.abstract | Sophora flavescensis used as a traditional herbal medicine to modulate inflammatory responses. However, little is known about the impact of (-)-maackiain, a compound derived fromS. flavescens, on the activation of inflammasome/caspase-1, a key factor in interleukin-1 beta (IL-1 beta) processing. Here, we report that (-)-maackiain potently amplified caspase-1 cleavage in macrophages in response to nigericin (Nig). In macrophages primed with either lipopolysaccharide or monophosphoryl lipid A, Nig-mediated caspase-1 cleavage was also markedly promoted by (-)-maackiain. Notably, (-)-maackiain induced the production of vimentin, an essential mediator for the activation of the NOD-, LRR-, and pyrin domain-containing protein 3 inflammasome, thereby contributing to promotion of the formation of the inflammasome complex to activate caspase-1. Taken together, our data suggest that (-)-maackiain exerts an immunostimulatory effect by promoting IL-1 beta production via activation of the inflammasome/caspase-1 pathway. Thus, the potent inflammasome-activating effect of (-)-maackiain may be clinically useful as an acute immune-stimulating agent. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | INTERLEUKIN-1 FAMILY CYTOKINES | - |
dc.subject | SOPHORA-FLAVESCENS | - |
dc.subject | VACCINE ADJUVANTS | - |
dc.subject | INFLUENZA-VIRUS | - |
dc.subject | KURARINONE | - |
dc.subject | INDUCTION | - |
dc.subject | PATHWAYS | - |
dc.subject | IMMUNITY | - |
dc.subject | TOXINS | - |
dc.subject | GROWTH | - |
dc.title | Maackiain, a compound derived fromSophora flavescens, increases IL-1 beta production by amplifying nigericin-mediated inflammasome activation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jun, Hyun Sik | - |
dc.contributor.affiliatedAuthor | Ha, Un-Hwan | - |
dc.identifier.doi | 10.1002/2211-5463.12899 | - |
dc.identifier.scopusid | 2-s2.0-85087144403 | - |
dc.identifier.wosid | 000543219800001 | - |
dc.identifier.bibliographicCitation | FEBS OPEN BIO, v.10, no.8, pp.1482 - 1491 | - |
dc.relation.isPartOf | FEBS OPEN BIO | - |
dc.citation.title | FEBS OPEN BIO | - |
dc.citation.volume | 10 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1482 | - |
dc.citation.endPage | 1491 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | INTERLEUKIN-1 FAMILY CYTOKINES | - |
dc.subject.keywordPlus | SOPHORA-FLAVESCENS | - |
dc.subject.keywordPlus | VACCINE ADJUVANTS | - |
dc.subject.keywordPlus | INFLUENZA-VIRUS | - |
dc.subject.keywordPlus | KURARINONE | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | TOXINS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | (-)-maackiain | - |
dc.subject.keywordAuthor | inflammasome | - |
dc.subject.keywordAuthor | monophosphoryl lipid A | - |
dc.subject.keywordAuthor | nigericin | - |
dc.subject.keywordAuthor | Sophora flavescens | - |
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