Maackiain, a compound derived fromSophora flavescens, increases IL-1 beta production by amplifying nigericin-mediated inflammasome activation
- Authors
- Huh, Jin-Won; Lee, Jung-Hoon; Jeon, Eekhyoung; Ryu, Hyung Won; Oh, Sei-Ryang; Ahn, Kyung-Seop; Jun, Hyun Sik; Ha, Un-Hwan
- Issue Date
- 8월-2020
- Publisher
- WILEY
- Keywords
- (-)-maackiain; inflammasome; monophosphoryl lipid A; nigericin; Sophora flavescens
- Citation
- FEBS OPEN BIO, v.10, no.8, pp.1482 - 1491
- Indexed
- SCIE
SCOPUS
- Journal Title
- FEBS OPEN BIO
- Volume
- 10
- Number
- 8
- Start Page
- 1482
- End Page
- 1491
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/54274
- DOI
- 10.1002/2211-5463.12899
- ISSN
- 2211-5463
- Abstract
- Sophora flavescensis used as a traditional herbal medicine to modulate inflammatory responses. However, little is known about the impact of (-)-maackiain, a compound derived fromS. flavescens, on the activation of inflammasome/caspase-1, a key factor in interleukin-1 beta (IL-1 beta) processing. Here, we report that (-)-maackiain potently amplified caspase-1 cleavage in macrophages in response to nigericin (Nig). In macrophages primed with either lipopolysaccharide or monophosphoryl lipid A, Nig-mediated caspase-1 cleavage was also markedly promoted by (-)-maackiain. Notably, (-)-maackiain induced the production of vimentin, an essential mediator for the activation of the NOD-, LRR-, and pyrin domain-containing protein 3 inflammasome, thereby contributing to promotion of the formation of the inflammasome complex to activate caspase-1. Taken together, our data suggest that (-)-maackiain exerts an immunostimulatory effect by promoting IL-1 beta production via activation of the inflammasome/caspase-1 pathway. Thus, the potent inflammasome-activating effect of (-)-maackiain may be clinically useful as an acute immune-stimulating agent.
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Collections - Graduate School > Department of Biotechnology and Bioinformatics > 1. Journal Articles
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