Prognostic significance of interim PET/CT response for the treatment of advanced-stage marginal zone lymphoma in the post-rituximab era
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Ga-Young | - |
dc.contributor.author | Yoon, Sang Eun | - |
dc.contributor.author | Kim, Seok Jin | - |
dc.contributor.author | Kim, Jin Seok | - |
dc.contributor.author | Koh, Youngil | - |
dc.contributor.author | Moon, Joon-Ho | - |
dc.contributor.author | Oh, Sung Yong | - |
dc.contributor.author | Lee, Ho Sup | - |
dc.contributor.author | Shin, Ho-Jin | - |
dc.contributor.author | Do, Young Rok | - |
dc.contributor.author | Lee, Won Sik | - |
dc.contributor.author | Kim, Dae Sik | - |
dc.contributor.author | Park, Yong | - |
dc.contributor.author | Yhim, Ho-Young | - |
dc.contributor.author | Yang, Deok-Hwan | - |
dc.date.accessioned | 2021-08-30T19:16:21Z | - |
dc.date.available | 2021-08-30T19:16:21Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-07-15 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/54387 | - |
dc.description.abstract | There are still controversies about the use of interim positron emission tomography/computed tomography (PET/CT) in indolent non-Hodgkin lymphoma due to the variable fluorodeoxyglucose (FDG) avidity. Therefore, this study aimed to evaluate the roles of interim PET/CT in marginal zone lymphoma (MZL), a representative indolent lymphoma. We analyzed the data of 146 MZL patients. All were treated with rituximab-containing immunochemotherapy. Interim PET/CT scan was performed after 2-3 cycles of therapy, and the response was assessed using the Deauville 5-point scales (5-PS) and a semi-quantitative assessment using the SUVmax reduction rate (Delta SUVmax). Progression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p<0.001). Particularly, there was a significant difference in PFS between patients with interim score 1-2 and those with score 3. However, <Delta>SUVmax did not predict the survival outcome using 59.8% of the optimal cutoff value. In the multivariate analysis, failure to achievement of grade 1-2 in interim PET/CT was significantly associated with inferior PFS (HR, 2.154; 95% CI 1.071-4.332; p=0.031). The interim PET/CT response based on the 5-PS is useful for predicting PFS of patients with MZL in the post-rituximab era. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject | B-CELL LYMPHOMA | - |
dc.subject | HODGKIN-LYMPHOMA | - |
dc.subject | FDG-PET | - |
dc.subject | INTERPRETATION CRITERIA | - |
dc.subject | FOLLICULAR LYMPHOMA | - |
dc.subject | 18F-FDG PET/CT | - |
dc.subject | MALT LYMPHOMA | - |
dc.subject | THERAPY | - |
dc.subject | SCANS | - |
dc.title | Prognostic significance of interim PET/CT response for the treatment of advanced-stage marginal zone lymphoma in the post-rituximab era | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Dae Sik | - |
dc.contributor.affiliatedAuthor | Park, Yong | - |
dc.identifier.doi | 10.1038/s41598-020-68310-w | - |
dc.identifier.scopusid | 2-s2.0-85088023394 | - |
dc.identifier.wosid | 000550031000001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.10, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | B-CELL LYMPHOMA | - |
dc.subject.keywordPlus | HODGKIN-LYMPHOMA | - |
dc.subject.keywordPlus | FDG-PET | - |
dc.subject.keywordPlus | INTERPRETATION CRITERIA | - |
dc.subject.keywordPlus | FOLLICULAR LYMPHOMA | - |
dc.subject.keywordPlus | 18F-FDG PET/CT | - |
dc.subject.keywordPlus | MALT LYMPHOMA | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | SCANS | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.