Prognostic significance of interim PET/CT response for the treatment of advanced-stage marginal zone lymphoma in the post-rituximab era
- Authors
- Song, Ga-Young; Yoon, Sang Eun; Kim, Seok Jin; Kim, Jin Seok; Koh, Youngil; Moon, Joon-Ho; Oh, Sung Yong; Lee, Ho Sup; Shin, Ho-Jin; Do, Young Rok; Lee, Won Sik; Kim, Dae Sik; Park, Yong; Yhim, Ho-Young; Yang, Deok-Hwan
- Issue Date
- 15-7월-2020
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v.10, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 10
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/54387
- DOI
- 10.1038/s41598-020-68310-w
- ISSN
- 2045-2322
- Abstract
- There are still controversies about the use of interim positron emission tomography/computed tomography (PET/CT) in indolent non-Hodgkin lymphoma due to the variable fluorodeoxyglucose (FDG) avidity. Therefore, this study aimed to evaluate the roles of interim PET/CT in marginal zone lymphoma (MZL), a representative indolent lymphoma. We analyzed the data of 146 MZL patients. All were treated with rituximab-containing immunochemotherapy. Interim PET/CT scan was performed after 2-3 cycles of therapy, and the response was assessed using the Deauville 5-point scales (5-PS) and a semi-quantitative assessment using the SUVmax reduction rate (Delta SUVmax). Progression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p<0.001). Particularly, there was a significant difference in PFS between patients with interim score 1-2 and those with score 3. However, <Delta>SUVmax did not predict the survival outcome using 59.8% of the optimal cutoff value. In the multivariate analysis, failure to achievement of grade 1-2 in interim PET/CT was significantly associated with inferior PFS (HR, 2.154; 95% CI 1.071-4.332; p=0.031). The interim PET/CT response based on the 5-PS is useful for predicting PFS of patients with MZL in the post-rituximab era.
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