Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK/BDNF pathways
DC Field | Value | Language |
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dc.contributor.author | Kim, Suhyeon | - |
dc.contributor.author | Hong, Ki-Bae | - |
dc.contributor.author | Kim, Singeun | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Jo, Kyungae | - |
dc.date.accessioned | 2021-08-30T19:37:29Z | - |
dc.date.available | 2021-08-30T19:37:29Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-07-09 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/54408 | - |
dc.description.abstract | We investigated the antidepressant effect of creatine (CRE) and taurine (TAU) mixtures on behavioural changes and biomarkers in stress-induced depression in Drosophila melanogaster and a mouse model. Following CRE/TAU mixture administration in the Drosophila model, depression-like state induced by vibration, locomotion, climbing activity, and survival rate were measured. The normal stress (NS) group demonstrated decreased movement than the control (CON) group; movements in the CRE/TAU-treated group (particularly 0.15/0.5%) returned to the CON levels. Antidepressant effects of CRE/TAU mixtures were confirmed in a depressive mouse model induced by chronic mild stress. In behavioural assessments, movement and sucrose preference of the CRE/TAU group increased to a similar level as in the positive control group; hippocampal catecholamine and serotonin levels increased significantly. Stress-related hormones (adrenocorticotropic and corticotropin-releasing hormones) and inflammatory factors (IL-1 beta, IL-6, and TNF-alpha) increased in the NS group but significantly decreased in the CRE/TAU-treated group. Brain signalling protein expression ratio of phosphorylated protein kinase B (p-Akt)/Akt, phosphorylated extracellular signal-regulated kinase (p-ERK)/ERK, and brain-derived neurotrophic factor (BDNF) significantly increased in the CRE/TAU-treated group. These results indicate that CRE/TAU-induced antidepressant effects are associated with increased behavioural patterns and downregulation of stress hormones and cytokines, mediated through Akt and ERK/BDNF pathways in vertebrate models. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | BRAIN | - |
dc.subject | BDNF | - |
dc.subject | CORTICOSTERONE | - |
dc.subject | EXPRESSION | - |
dc.subject | CYTOKINES | - |
dc.subject | TRANSPORT | - |
dc.subject | DOPAMINE | - |
dc.subject | SLEEP | - |
dc.subject | MODEL | - |
dc.title | Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK/BDNF pathways | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1038/s41598-020-68424-1 | - |
dc.identifier.scopusid | 2-s2.0-85087707655 | - |
dc.identifier.wosid | 000548564900084 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.10, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | BDNF | - |
dc.subject.keywordPlus | CORTICOSTERONE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | DOPAMINE | - |
dc.subject.keywordPlus | SLEEP | - |
dc.subject.keywordPlus | MODEL | - |
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