Insights into Characterization Methods and Biomedical Applications of Nanoparticle-Protein Corona
- Authors
- Li, Yan; Lee, Jae-Seung
- Issue Date
- 7월-2020
- Publisher
- MDPI
- Keywords
- nanoparticles; protein corona; characterization; biomedical application
- Citation
- MATERIALS, v.13, no.14
- Indexed
- SCIE
SCOPUS
- Journal Title
- MATERIALS
- Volume
- 13
- Number
- 14
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/54846
- DOI
- 10.3390/ma13143093
- ISSN
- 1996-1944
- Abstract
- Nanoparticles (NPs) exposed to a biological milieu will strongly interact with proteins, forming "coronas" on the surfaces of the NPs. The protein coronas (PCs) affect the properties of the NPs and provide a new biological identity to the particles in the biological environment. The characterization of NP-PC complexes has attracted enormous research attention, owing to the crucial effects of the properties of an NP-PC on its interactions with living systems, as well as the diverse applications of NP-PC complexes. The analysis of NP-PC complexes without a well-considered approach will inevitably lead to misunderstandings and inappropriate applications of NPs. This review introduces methods for the characterization of NP-PC complexes and investigates their recent applications in biomedicine. Furthermore, the review evaluates these characterization methods based on comprehensive critical views and provides future perspectives regarding the applications of NP-PC complexes.
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Collections - College of Engineering > Department of Materials Science and Engineering > 1. Journal Articles
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