Visceral fat metabolic activity evaluated by F-18-FDG PET/CT is associated with osteoporosis in healthy postmenopausal Korean women
- Authors
- Pahk, Kisoo; Kwon, Yeongkeun; Kim, Meyoung-Kon; Park, Sungsoo; Kim, Sungeun
- Issue Date
- 7월-2020
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Obesity; Visceral fat; Osteoporosis; Postmenopause; F-18 FDG PET/CT; PET/CT
- Citation
- OBESITY RESEARCH & CLINICAL PRACTICE, v.14, no.4, pp.339 - 344
- Indexed
- SCIE
SCOPUS
- Journal Title
- OBESITY RESEARCH & CLINICAL PRACTICE
- Volume
- 14
- Number
- 4
- Start Page
- 339
- End Page
- 344
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/54949
- DOI
- 10.1016/j.orcp.2020.05.008
- ISSN
- 1871-403X
- Abstract
- Background: Traditionally, obesity has been regarded as protective against osteoporosis. However, recent accumulating evidences suggest that visceral obesity can increase the risk of osteoporosis and obesity-driven dysfunctional metabolic activity in visceral adipose tissue (VAT) is considered as a key underlying mechanism. Visceral obesity is known to increase during menopausal transition. F-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) is an established method to assess the degree of VAT metabolic activity. We aimed to investigate the association between VAT metabolic activity evaluated by F-18-FDG PET/CT and osteoporosis in healthy postmenopausal Korean women. Methods: A total of 115 postmenopausal women who underwent routine health check-up were enrolled in this study, retrospectively. They all underwent dual-energy X-ray absorptiometry and F-18-FDG PET/CT. Osteoporosis was defined as bone mineral density (BMD) T-score = -2.5 at either lumbar spine or femoral neck. VAT metabolic activity was defined as the maximum standardized uptake value (SUVmax) of VAT divided by the SUVmax of subcutaneous adipose tissue (V/S ratio). Results: The participants with osteoporosis showed significantly higher V/S ratio, age, body mass index, waist circumference, and postmenopausal period than the participants without osteoporosis. V/S ratio of 1.33 was proposed as an optimal cut-off value for identifying osteoporosis. Furthermore, V/S ratio was the most significant predictive factor for osteoporosis in postmenopausal woman by uni-and multivariate analyses. Interestingly, V/S ratio showed significant positive correlation with high sensitivity C-reactive protein, a surrogate marker for systemic inflammation. Conclusion: VAT metabolic activity assessed by F-18-FDG PET/CT is associated with osteoporosis in healthy postmenopausal Korean women. (C) 2020 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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