Intra-mitochondrial self-assembly to overcome the intracellular enzymatic degradation ofl-peptides
DC Field | Value | Language |
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dc.contributor.author | Jeena, M. T. | - |
dc.contributor.author | Lee, Seokyoung | - |
dc.contributor.author | Barui, Ayan Kumar | - |
dc.contributor.author | Jin, Seongeon | - |
dc.contributor.author | Cho, Yuri | - |
dc.contributor.author | Hwang, Suk-Won | - |
dc.contributor.author | Kim, Sehoon | - |
dc.contributor.author | Ryu, Ja-Hyoung | - |
dc.date.accessioned | 2021-08-30T21:22:50Z | - |
dc.date.available | 2021-08-30T21:22:50Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-06-11 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/55027 | - |
dc.description.abstract | The design of peptide-based therapeutics is generally based on the replacement ofl-amino acids withd-isomers to obtain improved therapeutic efficiency. However,d-isomers are expensive and frequently induce undesirable immune responses. In the present work, we demonstrate that an intra-mitochondrially self-assembling amphiphilic peptide exhibits analogous activity in bothd- andl-isomeric forms. This outcome is in contrast to the general observation considering higher therapeutic efficiencies ofd-isomers compared withl-analogues. This suggests thatl-peptides overcome proteolytic degradation during intra-mitochondrial self-assembly bothin vitroandin vivo. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | D-AMINO ACIDS | - |
dc.subject | CELLULAR UPTAKE | - |
dc.subject | DELIVERY | - |
dc.subject | BIODISTRIBUTION | - |
dc.title | Intra-mitochondrial self-assembly to overcome the intracellular enzymatic degradation ofl-peptides | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Suk-Won | - |
dc.contributor.affiliatedAuthor | Kim, Sehoon | - |
dc.identifier.doi | 10.1039/d0cc02029j | - |
dc.identifier.scopusid | 2-s2.0-85086346489 | - |
dc.identifier.wosid | 000541419600017 | - |
dc.identifier.bibliographicCitation | CHEMICAL COMMUNICATIONS, v.56, no.46, pp.6265 - 6268 | - |
dc.relation.isPartOf | CHEMICAL COMMUNICATIONS | - |
dc.citation.title | CHEMICAL COMMUNICATIONS | - |
dc.citation.volume | 56 | - |
dc.citation.number | 46 | - |
dc.citation.startPage | 6265 | - |
dc.citation.endPage | 6268 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | D-AMINO ACIDS | - |
dc.subject.keywordPlus | CELLULAR UPTAKE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
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