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Intra-mitochondrial self-assembly to overcome the intracellular enzymatic degradation ofl-peptides

Authors
Jeena, M. T.Lee, SeokyoungBarui, Ayan KumarJin, SeongeonCho, YuriHwang, Suk-WonKim, SehoonRyu, Ja-Hyoung
Issue Date
11-6월-2020
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.56, no.46, pp.6265 - 6268
Indexed
SCIE
SCOPUS
Journal Title
CHEMICAL COMMUNICATIONS
Volume
56
Number
46
Start Page
6265
End Page
6268
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/55027
DOI
10.1039/d0cc02029j
ISSN
1359-7345
Abstract
The design of peptide-based therapeutics is generally based on the replacement ofl-amino acids withd-isomers to obtain improved therapeutic efficiency. However,d-isomers are expensive and frequently induce undesirable immune responses. In the present work, we demonstrate that an intra-mitochondrially self-assembling amphiphilic peptide exhibits analogous activity in bothd- andl-isomeric forms. This outcome is in contrast to the general observation considering higher therapeutic efficiencies ofd-isomers compared withl-analogues. This suggests thatl-peptides overcome proteolytic degradation during intra-mitochondrial self-assembly bothin vitroandin vivo.
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