Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure
- Authors
- Kim, Junyoung; Kim, Sunwon; Song, Joon Woo; Kim, Hyun Jung; Lee, Min Woo; Han, Jeongmoo; Kim, Jin Won; Yoo, Hongki
- Issue Date
- 8-6월-2020
- Publisher
- NATURE RESEARCH
- Citation
- SCIENTIFIC REPORTS, v.10, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 10
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/55043
- DOI
- 10.1038/s41598-020-65742-2
- ISSN
- 2045-2322
- Abstract
- Micro-optical coherence tomography (mu OCT) is a novel imaging approach enabling visualization of the microstructures of biological tissues at a cellular or sub-cellular level. However, it has been challenging to develop a miniaturized flexible endoscopic mu OCT probe allowing helical luminal scanning. In this study, we built a flexible endoscopic mu OCT probe with an outer diameter of 1.2 mm, which acquires three-dimensional images of the arterial microstructures via helical scanning with an axial and lateral resolutions of 1.83 mu m and 3.38 mu m in air, respectively. Furthermore, the depth of focus of the mu OCT imaging probe was extended two-fold using a binary phase spatial filter. We demonstrated that the present endoscopic mu OCT could image cellular level features of a rabbit artery with high-risk atheroma and a bioresorbable scaffold-implanted swine coronary artery. This highly-translatable endoscopic mu OCT will be a useful tool for investigating coronary artery disease and stent biology.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.