Asthma control test reflects not only lung function but also airway inflammation in children with stable asthma
- Authors
- Lee, Woo Yeon; Suh, Dong In; Song, Dae Jin; Baek, Hey-Sung; Shin, Meeyong; Yoo, Young; Kwon, Ji-Won; Jang, Gwang Cheon; Yang, Hyeon-Jong; Lee, Eun; Seo, Ju-Hee; Woo, Sung-Il; Kim, Hyung Young; Shin, Youn Ho; Lee, Ju Suk; Yoon, Jisun; Jung, Sungsu; Han, Minkyu; Eom, Eunjin; Yu, Jinho; Kim, Woo Kyung; Lim, Dae Hyun; Kim, Jin Tack; Chang, Woo-Sung; Lee, Jeom-Kyu; Kim, Hwan Soo
- Issue Date
- 2-6월-2020
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Asthma control test; children; fractional exhaled nitric oxide; spirometry; bronchial hyperreactivity; bronchodilator response
- Citation
- JOURNAL OF ASTHMA, v.57, no.6, pp.648 - 653
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ASTHMA
- Volume
- 57
- Number
- 6
- Start Page
- 648
- End Page
- 653
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/55060
- DOI
- 10.1080/02770903.2019.1599386
- ISSN
- 0277-0903
- Abstract
- Objective: Various numerical asthma control tools have been developed to distinguish different levels of symptom control. We aimed to examine whether the asthma control test (ACT) is reflective of objective findings such as lung function, fractional exhaled nitric oxide (FeNO) and laboratory data in patients with stable asthma. Methods: We included patients who were enrolled in the Korean Childhood Asthma Study. ACT, spirometry, blood tests and FeNO were performed in patients after stabilization of their asthma. We examined differences among spirometry parameters, blood tests and FeNO according to control status as determined by ACT and investigated for any significant correlations. Results: The study population consisted of 441 subjects. Spirometry showed that forced expiratory volume in one second (FEV1), forced expiratory flow between 25% and 75% of forced vital capacity and FEV1/forced vital capacity were all significantly higher in the controlled asthma group. Likewise, FeNO and percent-change in FEV1 were both significantly lower in the controlled asthma group. In blood tests, the eosinophil fraction was significantly lower in the controlled asthma group while white blood cell count was significantly higher in the controlled asthma group. Lastly, among the various factors analyzed, only provocative concentration of methacholine causing a 20% fall in FEV1 significantly correlated with ACT score. Conclusion: ACT is useful as part of the routine evaluation of asthmatic children and should be used as a complement to existing tools such as spirometry and FeNO measurement.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.