Genetic Study in Korean Pediatric Patients with Steroid-Resistant Nephrotic Syndrome or Focal Segmental Glomerulosclerosis
- Authors
- Park, Eujin; Lee, Chung; Kim, Nayoung K. D.; Ahn, Yo Han; Park, Young Seo; Lee, Joo Hoon; Kim, Seong Heon; Cho, Min Hyun; Cho, Heeyeon; Yoo, Kee Hwan; Shin, Jae Il; Kang, Hee Gyung; Ha, Il-Soo; Park, Woong-Yang; Cheong, Hae Il
- Issue Date
- 6월-2020
- Publisher
- MDPI
- Keywords
- steroid-resistant nephrotic syndrome; focal segmental glomerulosclerosis; genetic analysis
- Citation
- JOURNAL OF CLINICAL MEDICINE, v.9, no.6
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- Volume
- 9
- Number
- 6
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/55108
- DOI
- 10.3390/jcm9062013
- ISSN
- 2077-0383
- Abstract
- Steroid-resistant nephrotic syndrome (SRNS) is one of the major causes of end-stage renal disease (ESRD) in childhood and is mostly associated with focal segmental glomerulosclerosis (FSGS). More than 50 monogenic causes of SRNS or FSGS have been identified. Recently, the mutation detection rate in pediatric patients with SRNS has been reported to be approximately 30%. In this study, genotype-phenotype correlations in a cohort of 291 Korean pediatric patients with SRNS/FSGS were analyzed. The overall mutation detection rate was 43.6% (127 of 291 patients).WT1was the most common causative gene (23.6%), followed byCOQ6(9.4%),NPHS1(8.7%),NUP107(7.1%), andCOQ8B(6.3%). Mutations inCOQ6,NUP107, andCOQ8Bwere more frequently detected, and mutations inNPHS2were less commonly detected in this cohort than in study cohorts from Western countries. The mutation detection rate was higher in patients with congenital onset, those who presented with proteinuria or chronic kidney disease/ESRD, and those who did not receive steroid treatment. Genetic diagnosis in patients with SRNS provides not only definitive diagnosis but also valuable information for decisions on treatment policy and prediction of prognosis. Therefore, further genotype-phenotype correlation studies are required.
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