Achievement of LDL-C Targets Defined by ESC/EAS (2011) Guidelines in Risk-Stratified Korean Patients with Dyslipidemia Receiving Lipid-Modifying Treatments
- Authors
- Yang, Ye Seul; Lee, Seo Young; Kim, Jung-Sun; Choi, Kyung Mook; Lee, Kang Wook; Lee, Sang-Chol; Cho, Jung Rae; Oh, Seung-Jin; Kim, Ji-Hyun; Choi, Sung Hee
- Issue Date
- 6월-2020
- Publisher
- KOREAN ENDOCRINE SOC
- Keywords
- Dyslipidemias; Cholesterol; LDL; Hydroxymethylglutaryl-CoA reductase inhibitors; Practice guideline; Risk assessment; Korea
- Citation
- ENDOCRINOLOGY AND METABOLISM, v.35, no.2, pp.367 - 376
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ENDOCRINOLOGY AND METABOLISM
- Volume
- 35
- Number
- 2
- Start Page
- 367
- End Page
- 376
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/55411
- DOI
- 10.3803/EnM.2020.35.2.367
- ISSN
- 2093-596X
- Abstract
- Background: This study assessed the proportion of risk-stratified Korean patients with dyslipidemia achieving their low-density lipoprotein cholesterol (LDL-C) targets as defined by the European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) (2011) guidelines while receiving lipid-modifying treatments (LMTs). Methods: In this multicenter, cross-sectional, observational study, we evaluated data from Korean patients aged >= 19 years who were receiving LMTs for >= 3 months and had an LDL-C value within the previous 12 months on the same LMT. Data were collected for demographics, cardiovascular (CV) risk factors, medical history', and healthcare consumption Patients were risk-stratified according to the ESC Systematic COronary Risk Evaluation (SCORE) chart and LDL-C target achievement rate was assessed. Results: Guideline-based risk-stratification of the 1,034 patients showed the majority (72.2%) to be in the very high-risk category'. Investigators' assessment of risk was underestimated in 71.6% compared to ESC/EAS guidelines. Overall LDL-C target achievement rate was 44.3%; target achievement was the highest (66.0%) in moderate-risk patients and the lowest (39.0%) in very high-risk patients. Overall 97.1% patients were receiving statin therapy, mostly as a single-agent (89.2%). High-intensity statins and the highest permissible dose of high-intensity statin had been prescribed to only 9.1% and 7.3% patients in the very high-risk group, respectively. Physician satisfaction with patients' LDL-C levels was the primary reason for non-intensification of statin therapy. Conclusion: Achievement of target LDL-C level is suboptimal in Korean patients with dyslipidemia, especially in those at very high-risk of CV events. Current practices in LMTs need to be improved based on precise CV risk evaluation posed by dyslipidemia.
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