MDM2-Associated Clusterization-Triggered Emission and Apoptosis Induction Effectuated by a Theranostic Spiropolymer
DC Field | Value | Language |
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dc.contributor.author | Liu, Pai | - |
dc.contributor.author | Fu, Weiqiang | - |
dc.contributor.author | Verwilst, Peter | - |
dc.contributor.author | Won, Miae | - |
dc.contributor.author | Shin, Jinwoo | - |
dc.contributor.author | Cai, Zhengxu | - |
dc.contributor.author | Tong, Bin | - |
dc.contributor.author | Shi, Jianbing | - |
dc.contributor.author | Dong, Yuping | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2021-08-30T23:15:18Z | - |
dc.date.available | 2021-08-30T23:15:18Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-05-25 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/55639 | - |
dc.description.abstract | Heteroatom-containing spiropolymers were constructed in a facile manner by a catalyst-free multicomponent spiropolymerization route. P1a2b as the most potent of these spiropolymers, demonstrates cluster-triggered emission resulting from strong interactions with the MDM2 protein. By preventing the anti-apoptotic p53/MDM2 interaction, P1a2b triggers apoptosis in cancerous cells, while demonstrating a good biocompatibility and non-toxicity in non-cancerous cells. The combined results from solution and cell-based cluster-triggered emission studies, docking, protein expression experiments and cytotoxicity data strongly support the MDM2-binding hypothesis and indicate a potential application as a fluorescent cancer marker as well as therapeutic for this spiropolymer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | INHIBITORS | - |
dc.subject | DESIGN | - |
dc.subject | P53 | - |
dc.subject | DERIVATIVES | - |
dc.subject | POLYMERS | - |
dc.subject | POTENT | - |
dc.title | MDM2-Associated Clusterization-Triggered Emission and Apoptosis Induction Effectuated by a Theranostic Spiropolymer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Won, Miae | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1002/anie.201916524 | - |
dc.identifier.scopusid | 2-s2.0-85082324800 | - |
dc.identifier.wosid | 000532831400015 | - |
dc.identifier.bibliographicCitation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.59, no.22, pp.8435 - 8439 | - |
dc.relation.isPartOf | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.citation.title | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.citation.volume | 59 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 8435 | - |
dc.citation.endPage | 8439 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | POTENT | - |
dc.subject.keywordAuthor | cell apoptosis | - |
dc.subject.keywordAuthor | clusterization-triggered emission | - |
dc.subject.keywordAuthor | MDM2 inhibitor | - |
dc.subject.keywordAuthor | spiropolymerization | - |
dc.subject.keywordAuthor | theranostics | - |
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