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MDM2-Associated Clusterization-Triggered Emission and Apoptosis Induction Effectuated by a Theranostic Spiropolymer

Authors
Liu, PaiFu, WeiqiangVerwilst, PeterWon, MiaeShin, JinwooCai, ZhengxuTong, BinShi, JianbingDong, YupingKim, Jong Seung
Issue Date
25-5월-2020
Publisher
WILEY-V C H VERLAG GMBH
Keywords
cell apoptosis; clusterization-triggered emission; MDM2 inhibitor; spiropolymerization; theranostics
Citation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.59, no.22, pp.8435 - 8439
Indexed
SCIE
SCOPUS
Journal Title
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume
59
Number
22
Start Page
8435
End Page
8439
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/55639
DOI
10.1002/anie.201916524
ISSN
1433-7851
Abstract
Heteroatom-containing spiropolymers were constructed in a facile manner by a catalyst-free multicomponent spiropolymerization route. P1a2b as the most potent of these spiropolymers, demonstrates cluster-triggered emission resulting from strong interactions with the MDM2 protein. By preventing the anti-apoptotic p53/MDM2 interaction, P1a2b triggers apoptosis in cancerous cells, while demonstrating a good biocompatibility and non-toxicity in non-cancerous cells. The combined results from solution and cell-based cluster-triggered emission studies, docking, protein expression experiments and cytotoxicity data strongly support the MDM2-binding hypothesis and indicate a potential application as a fluorescent cancer marker as well as therapeutic for this spiropolymer.
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