Phenylpropanoid-Conjugated Triterpenoids from the Leaves of Actinidia arguta and Their Inhibitory Activity on alpha-Glucosidase
- Authors
- Ahn, Jong Hoon; Park, Youngki; Yeon, Sang Won; Jo, Yang Hee; Han, Yoo Kyong; Turk, Ayman; Ryu, Se Hwan; Hwang, Bang Yeon; Lee, Ki Yong; Lee, Mi Kyeong
- Issue Date
- 22-5월-2020
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.83, no.5, pp.1416 - 1423
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 83
- Number
- 5
- Start Page
- 1416
- End Page
- 1423
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/55647
- DOI
- 10.1021/acs.jnatprod.9b00643
- ISSN
- 0163-3864
- Abstract
- Actinidia arguta, commonly called hardy kiwifruit or kiwiberry, has cold-resistant properties and can be cultivated in Asia, including Korea. Seven new triterpenoids (2-4 and 8-11) along with eight known triterpenoids were isolated from the leaves of A. arguta through various chromatographic techniques. The new triterpenoids were defined as actiniargupenes A-C (2-4), actinidic acid derivatives with phenylpropanoid constituent units, dehydroisoactinidic acid (8), and actiniargupenes D-F (9-11), asiatic acid derivatives with phenylpropanoid substituents, on the basis of 1D and 2D NMR and MS data. Among the triterpenoids, those with a phenylpropanoid constituent unit showed inhibitory activity on alpha-glucosidase, which suggested the importance of the phenylpropanoid moiety. Molecular docking analysis demonstrated the interaction between the 4'-OH group of the phenylpropanoid moiety and alpha-glucosidase.
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