Lysine-specific demethylase 3A is important for autophagic occurrence
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Joomyung | - |
dc.contributor.author | Choi, Seon Ah | - |
dc.contributor.author | Kim, Jaebeom | - |
dc.contributor.author | Kim, Hyunkyung | - |
dc.contributor.author | Baek, Sung Hee | - |
dc.date.accessioned | 2021-08-30T23:17:36Z | - |
dc.date.available | 2021-08-30T23:17:36Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-05-21 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/55655 | - |
dc.description.abstract | Autophagy is an essential process to maintain cell survival and homeostasis under various stress conditions. Here, we report that lysine-specific demethylase 3A (KDM3A) plays an important role in starvation-induced autophagy. Using Kdm3a knockout mice, we demonstrate that KDM3A is crucial for proper hepatic autophagy in vivo. Hepatic mRNA expression analysis and ChIP assay in WT and Kdm3a knockout mouse livers reveal that KDM3A activates autophagy genes by reducing histone H3K9me2 levels upon fasting. Together, our finding represents previously unidentified function of KDM3A as a key regulator of autophagy, implicating potential therapeutic approaches for autophagy-related diseases. (C) 2020 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | EPIGENETIC REGULATION | - |
dc.subject | HISTONE | - |
dc.subject | JHDM2A | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | RECEPTOR | - |
dc.subject | KDM3A | - |
dc.title | Lysine-specific demethylase 3A is important for autophagic occurrence | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyunkyung | - |
dc.identifier.doi | 10.1016/j.bbrc.2020.03.058 | - |
dc.identifier.scopusid | 2-s2.0-85081961338 | - |
dc.identifier.wosid | 000530586500028 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.526, no.1, pp.176 - 183 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 526 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 176 | - |
dc.citation.endPage | 183 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | EPIGENETIC REGULATION | - |
dc.subject.keywordPlus | HISTONE | - |
dc.subject.keywordPlus | JHDM2A | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | KDM3A | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | KDM3A | - |
dc.subject.keywordAuthor | H3K9 demethylation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.