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Lysine-specific demethylase 3A is important for autophagic occurrence

Authors
Kim, JoomyungChoi, Seon AhKim, JaebeomKim, HyunkyungBaek, Sung Hee
Issue Date
21-5월-2020
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Autophagy; KDM3A; H3K9 demethylation
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.526, no.1, pp.176 - 183
Indexed
SCIE
SCOPUS
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
526
Number
1
Start Page
176
End Page
183
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/55655
DOI
10.1016/j.bbrc.2020.03.058
ISSN
0006-291X
Abstract
Autophagy is an essential process to maintain cell survival and homeostasis under various stress conditions. Here, we report that lysine-specific demethylase 3A (KDM3A) plays an important role in starvation-induced autophagy. Using Kdm3a knockout mice, we demonstrate that KDM3A is crucial for proper hepatic autophagy in vivo. Hepatic mRNA expression analysis and ChIP assay in WT and Kdm3a knockout mouse livers reveal that KDM3A activates autophagy genes by reducing histone H3K9me2 levels upon fasting. Together, our finding represents previously unidentified function of KDM3A as a key regulator of autophagy, implicating potential therapeutic approaches for autophagy-related diseases. (C) 2020 Elsevier Inc. All rights reserved.
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