Prevalence and complications of nonsurgical hypoparathyroidism in Korea: A nationwide cohort study
- Authors
- Kim, Se Hwa; Rhee, Yumie; Kim, Yoo Mee; Won, Young Jun; Noh, Junghyun; Moon, Hyemi; Lee, Juneyoung; Kim, Sin Gon
- Issue Date
- 8-5월-2020
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v.15, no.5
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLOS ONE
- Volume
- 15
- Number
- 5
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/56023
- DOI
- 10.1371/journal.pone.0232842
- ISSN
- 1932-6203
- Abstract
- Objective The risk of complications of nonsurgical hypoparathyroidism in Asia is unclear. We estimated the prevalence and risk of complications in patients with nonsurgical hypoparathyroidism. Methods We performed a retrospective cohort study using a nationwide claims database from 2005 to 2016. Among the entire Korean population, we identified 897 patients diagnosed with nonsurgical hypoparathyroidism during 2005-2015. We selected 210 patients with nonsurgical hypoparathyroidism during 2005-2008 who had no complications at baseline and followed them to 2016. Control subjects (n = 2075) were matched using propensity scores based on age, sex, and comorbid disease with a 1:10 ratio and monitored until 2016. Results The age-standardized prevalence of nonsurgical hypoparathyroidism was 0.2 cases per 100,000 persons in 2005. During a mean follow-up period of 9.5 years, patients with nonsurgical hypoparathyroidism had a higher risk of cardiovascular disease, especially arrhythmia (hazard ratio [HR], 2.03; 95% confidence interval [CI], 1.11-3.70) and heart failure (HR, 2.43; 95% CI, 1.22-4.83). The risk of vertebral fracture was higher in patients than in controls (HR, 2.27; 95% CI, 1.09-4.72). Patients had a significantly increased risk of renal disease (HR, 2.57; 95% CI, 1.56-4.21), seizure (HR, 5.74; 95% CI, 3.34-9.86), depression and bipolar disease (HR, 1.82; 95% CI, 1.30-2.56), and cataract (HR, 1.90; 95% CI, 1.30-2.79) compared with controls. Conclusions The prevalence of nonsurgical hypoparathyroidism was very low in Korea but was associated with a higher risk of incident cardiovascular disease and vertebral fracture as well as known complications including renal disease, seizure, and cataract.
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