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Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013

Authors
Kim, BongyoungHwang, HyeonjunKim, JieunLee, Myoung-jaePai, Hyunjoo
Issue Date
5월-2020
Publisher
KOREAN ASSOC INTERNAL MEDICINE
Keywords
Anti-bacterial agents; Hospitals; Korea
Citation
KOREAN JOURNAL OF INTERNAL MEDICINE, v.35, no.3, pp.703 - +
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL OF INTERNAL MEDICINE
Volume
35
Number
3
Start Page
703
End Page
+
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/56079
DOI
10.3904/kjim.2017.332
ISSN
1226-3303
Abstract
Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea. Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each class of antibiotic was converted to defined daily dose (DDD)/1.,000 patient-days. We defined 3rd generation cephalosporins, 4th generation cephalosporins, beta-lactam/beta-lactamase inhibitors, and fluoroquinolones as broad-spectrum antibiotics; carbapenems, tigecycline, glycopeptides, oxazolidinone, and polymyxin were defined as antibiotics against multidrug-resistant (MDR) pathogens. Other antibiotic classes were defined as nonbroad-spectrum antibiotics. Results: Mean antibiotic consumption was 920.69 DDD/1,000 patient-days. The proportions of broad-spectrum antibiotics, antibiotics against MDR pathogens, and nonbroad-spectrum antibiotics were 41.8% (384.48/920.69), 3.5% (32.24/920.69), and 54.7% (503.97/920.69), respectively. Consumption of broad-spectrum antibiotics (coefficient for time 0.141; p = 0.049) and antibiotics against MDR pathogens (coefficient for time 0.185; p < 0.001) showed a significant increasing trend over the study period. Nonbroad-spectrum antibiotic consumption showed a significant decreasing trend over the study period (coefficient for time -2.601; p < 0.001). Conclusions: Over the 10-year period, a stepwise increase in the consumption of broad-spectrum antibiotics and antibiotics against MDR pathogens was observed at a tertiary care hospital in Korea. Conversely, during the same period, nonbroad-spectrum antibiotic consumption showed a significant decreasing trend.
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