Risk factors for primary lung cancer among never- smoking women in South Korea: a retrospective nationwide population-based cohort study
- Authors
- Ko, Yoon Ho; Kim, Seung Joon; Kim, Wan-Seop; Park, Chan Kwon; Park, Cheol-Kyu; Suh, Yang-Gun; Eom, Jung Seop; Cho, Sukki; Hur, Jae Young; Hwang, Sung Ho; Myong, Jun-Pyo
- Issue Date
- 5월-2020
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Keywords
- Lung neoplasm; Never-smoking women; Risk factor; Cohort studies
- Citation
- KOREAN JOURNAL OF INTERNAL MEDICINE, v.35, no.3, pp.692 - 702
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- Volume
- 35
- Number
- 3
- Start Page
- 692
- End Page
- 702
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/56083
- DOI
- 10.3904/kjim.2019.283
- ISSN
- 1226-3303
- Abstract
- Background/Aims: We performed a large-scale, retrospective, nationwide, cohort study to investigate the risk factors for lung cancer among never-smoking Korean females. Methods: The study data were collected from a general health examination and questionnaire survey of eligible populations conducted between January 1, 2003 and December 31, 2004; the data were acquired from the tailored big data distribution service of the National Health Insurance Service. After a 1-year clearance period, 5,860,922 of 6,318,878 never-smoking female participants with no previous history of lung cancer were investigated. After a median follow-up of 11.4 years, 43,473 (0.74%) participants were defined as "newly diagnosed lung cancer". Results: After adjusting for all variables at baseline, the variables older age, lower body mass index (BMI), less exercise, frequent alcohol drinking, meat-based diet, rural residence, and previous history of cancer were associated with a higher incidence of lung cancer. Low BMI (< 18.5 kg/m(2): hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.27 to 1.40) was a significant independent risk factor; as BMI decreased, HR increased. Negative associations between BMI and lung-cancer development were also observed after controlling for age (p for trend < 0.001). Drinking alcohol one to two times a week (HR, 1.25; 95% CI, 1.21 to 1.28) and eating a meat-based diet (HR, 1.08; 95% CI, 1.01 to 1.35) were associated with lung-cancer incidence. Conclusions: Modifiable baseline characteristics, such as BMI, exercise, alcohol consumption, and diet, are risk factors for lung-cancer development among never-smoking females. Thus, lifestyle modifications may help prevent lung cancer.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.