Long-term Effects of Bilateral Subthalamic Deep Brain Stimulation on Postural Instability and Gait Difficulty in Patients with Parkinson's Disease
DC Field | Value | Language |
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dc.contributor.author | Shin, Hae-Won | - |
dc.contributor.author | Kim, Mi Sun | - |
dc.contributor.author | Kim, Sung Reul | - |
dc.contributor.author | Jeon, Sang Ryong | - |
dc.contributor.author | Chung, Sun Ju | - |
dc.date.accessioned | 2021-08-31T01:32:57Z | - |
dc.date.available | 2021-08-31T01:32:57Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 2005-940X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/56147 | - |
dc.description.abstract | Objective The long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on postural instability and gait difficulty (PIGD) in patients with Parkinson's disease (PD) remain unclear. In this study, we aimed to evaluate the long-term effects of STN-DBS surgery on PIGD symptoms in patients with advanced-stage PD. Methods This study included 49 consecutively included patients with PD who underwent bilateral STN-DBS. The Unified Parkinson's Disease Rating Scale (UPDRS) scores and subscores for PIGD were assessed at baseline and at 1, 3, and 5 years post-operatively. The PIGD subscore was divided into PIGD-motor and PIGD-activities of daily living (ADL) scores according to parts III and II of the UPDRS, respectively. Results The PIGD-motor and PIGD-ADL scores at the "medication-off" state improved at 3 and 5 years, respectively. Overall, the UPDRS III and II scores at "medication-off" improved at 5 years. The UPDRS IV score also significantly improved and the levodopa equivalent daily dosage decreased at all follow-ups. Finally, the PIGD-motor score at baseline was able to predict long-term improvement in the PIGD-motor score at the 5-year follow-up. Conclusion The STN-DBS has both short- and long-term effects on PIGD, as well as overall motor function, in patients with advanced PD. The degree of PIGD at the preoperative evaluation can be used to predict long-term outcomes after STN-DBS surgery. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN MOVEMENT DISORDERS SOC | - |
dc.subject | NUCLEUS STIMULATION | - |
dc.subject | BALANCE | - |
dc.subject | MOTOR | - |
dc.subject | NEUROSTIMULATION | - |
dc.subject | LEVODOPA | - |
dc.subject | THERAPY | - |
dc.title | Long-term Effects of Bilateral Subthalamic Deep Brain Stimulation on Postural Instability and Gait Difficulty in Patients with Parkinson's Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sung Reul | - |
dc.identifier.doi | 10.14802/jmd.19081 | - |
dc.identifier.scopusid | 2-s2.0-85090980489 | - |
dc.identifier.wosid | 000538007200006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MOVEMENT DISORDERS, v.13, no.2, pp.127 - 132 | - |
dc.relation.isPartOf | JOURNAL OF MOVEMENT DISORDERS | - |
dc.citation.title | JOURNAL OF MOVEMENT DISORDERS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 127 | - |
dc.citation.endPage | 132 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002589455 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | NUCLEUS STIMULATION | - |
dc.subject.keywordPlus | BALANCE | - |
dc.subject.keywordPlus | MOTOR | - |
dc.subject.keywordPlus | NEUROSTIMULATION | - |
dc.subject.keywordPlus | LEVODOPA | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Parkinson disease | - |
dc.subject.keywordAuthor | Deep brain stimulation | - |
dc.subject.keywordAuthor | Subthalamic nucleus | - |
dc.subject.keywordAuthor | Postural instability | - |
dc.subject.keywordAuthor | Gait difficulty | - |
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