Long-term Effects of Bilateral Subthalamic Deep Brain Stimulation on Postural Instability and Gait Difficulty in Patients with Parkinson's Disease
- Authors
- Shin, Hae-Won; Kim, Mi Sun; Kim, Sung Reul; Jeon, Sang Ryong; Chung, Sun Ju
- Issue Date
- 5월-2020
- Publisher
- KOREAN MOVEMENT DISORDERS SOC
- Keywords
- Parkinson disease; Deep brain stimulation; Subthalamic nucleus; Postural instability; Gait difficulty
- Citation
- JOURNAL OF MOVEMENT DISORDERS, v.13, no.2, pp.127 - 132
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MOVEMENT DISORDERS
- Volume
- 13
- Number
- 2
- Start Page
- 127
- End Page
- 132
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/56147
- DOI
- 10.14802/jmd.19081
- ISSN
- 2005-940X
- Abstract
- Objective The long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on postural instability and gait difficulty (PIGD) in patients with Parkinson's disease (PD) remain unclear. In this study, we aimed to evaluate the long-term effects of STN-DBS surgery on PIGD symptoms in patients with advanced-stage PD. Methods This study included 49 consecutively included patients with PD who underwent bilateral STN-DBS. The Unified Parkinson's Disease Rating Scale (UPDRS) scores and subscores for PIGD were assessed at baseline and at 1, 3, and 5 years post-operatively. The PIGD subscore was divided into PIGD-motor and PIGD-activities of daily living (ADL) scores according to parts III and II of the UPDRS, respectively. Results The PIGD-motor and PIGD-ADL scores at the "medication-off" state improved at 3 and 5 years, respectively. Overall, the UPDRS III and II scores at "medication-off" improved at 5 years. The UPDRS IV score also significantly improved and the levodopa equivalent daily dosage decreased at all follow-ups. Finally, the PIGD-motor score at baseline was able to predict long-term improvement in the PIGD-motor score at the 5-year follow-up. Conclusion The STN-DBS has both short- and long-term effects on PIGD, as well as overall motor function, in patients with advanced PD. The degree of PIGD at the preoperative evaluation can be used to predict long-term outcomes after STN-DBS surgery.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Nursing > Department of Nursing > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.