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Mulberry Fruit Extract Promotes Serum HDL-Cholesterol Levels and Suppresses Hepatic microRNA-33 Expression in Rats Fed High Cholesterol/Cholic Acid Diet

Authors
Lee, SoojinLee, Mak-SoonChang, EugeneLee, YoonjinLee, JaerinKim, JiyeonKim, Chong-TaiKim, In-HwanKim, Yangha
Issue Date
5월-2020
Publisher
MDPI
Keywords
bile acid; cholesterol efflux; high-density lipoprotein cholesterol (HDL-C); mulberry fruit; microRNA-33
Citation
NUTRIENTS, v.12, no.5
Indexed
SCIE
SCOPUS
Journal Title
NUTRIENTS
Volume
12
Number
5
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/56229
DOI
10.3390/nu12051499
ISSN
2072-6643
Abstract
Serum high-density lipoprotein cholesterol (HDL-C) levels and cholesterol excretion are closely associated with the risk of cardiovascular complications. The specific aim of the present study was to investigate the cholesterol lowering effect of mulberry fruit in rats fed a high cholesterol/cholic acid diet. Four-week supplementation with mulberry fruit extract significantly decreased serum and hepatic cholesterol (TC), serum low-density lipoprotein cholesterol (LDL-C), and fecal bile acid levels without changes in body weight and food intake (p < 0.05). Mulberry fruit extract significantly inhibited hepatic sterol-regulatory element binding protein (Srebp) 2 gene expression and upregulated hepatic mRNA levels of liver X receptor alpha (Lxr-alpha), ATP-binding cassette transporter 5 (Abcg5), and cholesterol 7 alpha-hydroxylase (Cyp7a1), which are involved in hepatic bile acid synthesis and cholesterol metabolism (p < 0.05). In addition, hepatic microRNA-33 expression was significantly inhibited by supplementation of mulberry fruit extract (p < 0.05). These results suggest the involvement of miR-33, its associated hepatic bile acid synthesis, HDL formation, and cholesterol metabolism in mulberry fruit-mediated beneficial effects on serum and hepatic lipid abnormalities.
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Kim, In Hwan
보건과학대학 (바이오시스템의과학부)
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