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A fluorescent nanobiosensor for the facile analysis of m(6)A RNA demethylase activity

Authors
Yim, Seo-HeeCha, Hyung JinPark, Se-JinYim, YeajeeWoo, Jae-SungMin, Dal-Hee
Issue Date
30-4월-2020
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.56, no.34, pp.4716 - 4719
Indexed
SCIE
SCOPUS
Journal Title
CHEMICAL COMMUNICATIONS
Volume
56
Number
34
Start Page
4716
End Page
4719
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/56264
DOI
10.1039/c9cc10054g
ISSN
1359-7345
Abstract
RNA demethylase has recently been known to be associated with cancer development but its selective inhibitors as anti-cancer agents have rarely been investigated to date. Herein, we have developed a fluorescent nanobiosensor which enables efficient quantitative analysis of RNA demethylase ALKBH5 activity and shows a high potential for robust inhibitor screening.
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