Multiparametric MR Is a Valuable Modality for Evaluating Disease Severity of Nonalcoholic Fatty Liver Disease
- Authors
- Lee, Young-Sun; Yoo, Yang Jae; Jung, Young Kul; Kim, Ji Hoon; Seo, Yeon Seok; Yim, Hyung Joon; Kim, In Hee; Lee, Soo Yeon; Kim, Baek-Hui; Kim, Jeong Woo; Lee, Chang Hee; Yeon, Jong Eun; Kwon, So Young; Um, Soon Ho; Byun, Kwan Soo
- Issue Date
- 4월-2020
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Citation
- CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, v.11
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
- Volume
- 11
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/56808
- DOI
- 10.14309/ctg.0000000000000157
- ISSN
- 2155-384X
- Abstract
- INTRODUCTION: Because nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of chronic liver disease, noninvasive evaluations of its severity are immediately needed. This prospective cross-sectional study evaluated the effectiveness of noninvasive assessments of hepatic steatosis, fibrosis, and steatohepatitis. METHODS: Patients underwent laboratory tests, liver biopsy, transient elastography, andMRI. MultiparametricMR was used to measure MRI proton density fat fraction, MR spectroscopy, T1 mapping, and MR elastography (MRE). RESULTS: We enrolled 130 patients between October 2016 and July 2019. For the diagnosis of moderate-tosevere steatosis (grade >= 2), the area under the receiver operating characteristic curve (AUROC) was lower in controlled attenuation parameter (0.69; 95% confidence interval [CI], 0.60-0.76) than MRI proton density fat fraction (0.82; 95% CI, 0.75-0.89; P = 0.008) and MR spectroscopy (0.83; 95% CI, 0.75-0.89; P = 0.006). For the diagnosis of advanced fibrosis (stage >= 3), the AUROC of MRE (0.89; 95% CI, 0.83-0.94) was superior compared with those of the Fibrosis-4 index (0.77; 95% CI, 0.69-0.84; P = 0.010), NAFLD fibrosis score (0.81; 95% CI, 0.73-0.87; P = 0.043), and transient elastography (0.82; 95% CI, 0.74-0.88; P = 0.062). For detecting advanced fibrosis or nonalcoholic steatohepatitis, the AUROC of MRE (0.86; 95% CI, 0.79-0.91) was higher than that of TE (0.76; 95% CI, 0.68-0.83) with statistical significance (P = 0.018). DISCUSSION: Multiparametric MR accurately identified a severe form of NAFLD. Multiparametric MR can be a valuable noninvasive method for evaluating the severity of NAFLD.
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