Clinical outcomes of immunocompromised patients on extracorporeal membrane oxygenation support for severe acute respiratory failure
- Authors
- Na, Soo Jin; Park, So Hee; Hong, Sang-Bum; Cho, Woo Hyun; Lee, Sang-Min; Cho, Young-Jae; Park, Sunghoon; Koo, So-My; Park, Seung Yong; Chang, Youjin; Kang, Byung Ju; Kim, Jung-Hyun; Oh, Jin Young; Jung, Jae-Seung; Yoo, Jung-Wan; Sim, Yun Su; Jeon, Kyeongman
- Issue Date
- 4월-2020
- Publisher
- OXFORD UNIV PRESS INC
- Keywords
- Extracorporeal membrane oxygenation; Acute respiratory failure; Immunocompromised; Outcomes
- Citation
- EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, v.57, no.4, pp.788 - 795
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
- Volume
- 57
- Number
- 4
- Start Page
- 788
- End Page
- 795
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/56850
- DOI
- 10.1093/ejcts/ezz276
- ISSN
- 1010-7940
- Abstract
- OBJECTIVES: There are limited data regarding extracorporeal membrane oxygenation (ECMO) support in immunocompromised patients, despite an increase in ECMO use in patients with respiratory failure. The aim of this study was to investigate the clinical characteristics and outcomes of immunocompromised patients requiring ECMO support for severe acute respiratory failure. METHODS: Between January 2012 and December 2015, all consecutive adult patients with severe acute respiratory failure who underwent ECMO for respiratory support at 16 tertiary or university-affiliated hospitals in South Korea were enrolled retrospectively. The patients were divided into 2 groups based on the immunocompromised status at the time of ECMO initiation. In-hospital and 6-month mortalities were compared between the 2 groups. In addition, association of immunocompromised status with 6-month mortality was evaluated with logistic regression analysis. RESULTS: Among 461 patients, 118 (25.6%) were immunocompromised. Immunocompromised patients were younger and had lower haemoglobin and platelet counts than immunocompetent patients. Ventilatory parameters and the use of adjunctive/rescue therapies were similar between the 2 groups, but prone positioning was more commonly used in immunocompetent patients. Successful weaning rates from ECMO (46.6% vs 58.9%; P = 0.021) was lower and hospital mortality (66.1% vs 59.8%; P = 0.22) was higher in immunocompromised patients. In addition, immunocompromised status was associated with higher 6-month mortality (74.6% vs 64.7%, adjusted odds ratio 2.10, 95% confidence interval 1.02-4.35; P = 0.045). CONCLUSIONS: Immunocompromised patients treated with ECMO support for severe acute respiratory failure had poorer short- and long-term prognoses than did immunocompetent patients.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.