Transcriptional coactivator with PDZ-binding motif stimulates epidermal regeneration via induction of amphiregulin expression after ultraviolet damage
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyung Min | - |
dc.contributor.author | Oh, Ho Taek | - |
dc.contributor.author | Yoo, Gi Don | - |
dc.contributor.author | Hwang, Jun-Ha | - |
dc.contributor.author | Oh, Areum | - |
dc.contributor.author | Hwang, Eun Sook | - |
dc.contributor.author | Hong, Jeong-Ho | - |
dc.date.accessioned | 2021-08-31T05:59:52Z | - |
dc.date.available | 2021-08-31T05:59:52Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-03-26 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/57220 | - |
dc.description.abstract | Ultraviolet (UV) irradiation induces the proliferation and differentiation of keratinocytes in the basal layer of the epidermis, which increases epidermal thickness in skin regeneration. However, the mechanism underlying this phenomenon is not yet known in detail. In this study, we aimed to demonstrate that the transcriptional coactivator with PDZ-binding motif (TAZ) stimulates epidermal regeneration by increasing keratinocyte proliferation. During epidermal regeneration, TAZ is localized in the nucleus of keratinocytes of the basal layer and stimulates epidermal growth factor receptor (EGFR) signaling. TAZ depletion in keratinocytes decreased EGFR signaling activation, which delays epidermal regeneration. Interestingly, TAZ stimulated the transcription of amphiregulin (AREG), a ligand of EGFR, through TEAD-mediated transcriptional activation. Together, these results show that TAZ stimulates EGFR signaling through AREG induction, suggesting that it plays an important role in epidermal regeneration. (C) 2020 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | GROWTH-FACTOR RECEPTORS | - |
dc.subject | STEM-CELLS | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | HIPPO PATHWAY | - |
dc.subject | EGF-RECEPTOR | - |
dc.subject | SKIN | - |
dc.subject | TAZ | - |
dc.subject | ACTIVATION | - |
dc.subject | RADIATION | - |
dc.subject | MEDIATOR | - |
dc.title | Transcriptional coactivator with PDZ-binding motif stimulates epidermal regeneration via induction of amphiregulin expression after ultraviolet damage | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Jun-Ha | - |
dc.contributor.affiliatedAuthor | Hong, Jeong-Ho | - |
dc.identifier.doi | 10.1016/j.bbrc.2020.01.079 | - |
dc.identifier.scopusid | 2-s2.0-85078200680 | - |
dc.identifier.wosid | 000526788600037 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.524, no.1, pp.242 - 248 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 524 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 242 | - |
dc.citation.endPage | 248 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTORS | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | HIPPO PATHWAY | - |
dc.subject.keywordPlus | EGF-RECEPTOR | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | TAZ | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | MEDIATOR | - |
dc.subject.keywordAuthor | Skin regeneration | - |
dc.subject.keywordAuthor | UV damage | - |
dc.subject.keywordAuthor | EGFR signal | - |
dc.subject.keywordAuthor | AREG | - |
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