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Transcriptional coactivator with PDZ-binding motif stimulates epidermal regeneration via induction of amphiregulin expression after ultraviolet damage

Authors
Kim, Kyung MinOh, Ho TaekYoo, Gi DonHwang, Jun-HaOh, AreumHwang, Eun SookHong, Jeong-Ho
Issue Date
26-3월-2020
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Skin regeneration; UV damage; EGFR signal; AREG
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.524, no.1, pp.242 - 248
Indexed
SCIE
SCOPUS
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
524
Number
1
Start Page
242
End Page
248
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/57220
DOI
10.1016/j.bbrc.2020.01.079
ISSN
0006-291X
Abstract
Ultraviolet (UV) irradiation induces the proliferation and differentiation of keratinocytes in the basal layer of the epidermis, which increases epidermal thickness in skin regeneration. However, the mechanism underlying this phenomenon is not yet known in detail. In this study, we aimed to demonstrate that the transcriptional coactivator with PDZ-binding motif (TAZ) stimulates epidermal regeneration by increasing keratinocyte proliferation. During epidermal regeneration, TAZ is localized in the nucleus of keratinocytes of the basal layer and stimulates epidermal growth factor receptor (EGFR) signaling. TAZ depletion in keratinocytes decreased EGFR signaling activation, which delays epidermal regeneration. Interestingly, TAZ stimulated the transcription of amphiregulin (AREG), a ligand of EGFR, through TEAD-mediated transcriptional activation. Together, these results show that TAZ stimulates EGFR signaling through AREG induction, suggesting that it plays an important role in epidermal regeneration. (C) 2020 Elsevier Inc. All rights reserved.
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