Minor components of aminoglycosides: recent advances in their biosynthesis and therapeutic potential
- Authors
- Ban, Yeon Hee; Song, Myoung Chong; Park, Je Won; Yoon, Yeo Joon
- Issue Date
- 1-3월-2020
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- NATURAL PRODUCT REPORTS, v.37, no.3, pp.301 - 311
- Indexed
- SCIE
SCOPUS
- Journal Title
- NATURAL PRODUCT REPORTS
- Volume
- 37
- Number
- 3
- Start Page
- 301
- End Page
- 311
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/57348
- DOI
- 10.1039/c9np00041k
- ISSN
- 0265-0568
- Abstract
- There is significant demand for new aminoglycoside antibiotics due to the widespread emergence of multidrug-resistant Gram-negative bacteria and their high toxicity, but these are not easily accessible in nature because their biosynthetic gene clusters are less commonly found in actinomycetes than are other natural products. Mining minor aminoglycoside components whose pharmacological activity has not yet been assessed could be an alternative approach for the development of next-generation antibiotics for use in the post-antibiotic era. Here, we review the biosynthetic steps responsible for the structural diversity of aminoglycosides and highlight current developments regarding the use of natural minor and semi-synthetic aminoglycosides as promising therapeutic leads or candidates.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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