Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Romo1-Derived Antimicrobial Peptide Is a New Antimicrobial Agent against Multidrug-Resistant Bacteria in a Murine Model of Sepsis

Authors
Lee, Hye-RaYou, Deok-gyunKim, Hong KyuSohn, Jang WookKim, Min JaPark, Jong KukLee, Gi YoungYoo, Young Do
Issue Date
Mar-2020
Publisher
AMER SOC MICROBIOLOGY
Keywords
AMPR-11; antimicrobial peptide; drug resistance; multidrug-resistant bacteria; peptide antibiotics; sepsis
Citation
MBIO, v.11, no.2
Indexed
SCIE
SCOPUS
Journal Title
MBIO
Volume
11
Number
2
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/57446
DOI
10.1128/mBio.03258-19
ISSN
2161-2129
2150-7511
Abstract
To overcome increasing bacterial resistance to conventional antibiotics, many antimicrobial peptides (AMPs) derived from host defense proteins have been developed. However, there are considerable obstacles to their application to systemic infections because of their low bioavailability. In the present study, we developed an AMP derived from Romo1 (AMPR-11) that exhibits a broad spectrum of antimicrobial activity. AMPR-11 showed remarkable efficacy against sepsis-causing bacteria, including multidrug-resistant strains, with low toxicity in a murine model of sepsis after intravenous administration. It seems that AMPR-11 disrupts bacterial membranes by interacting with cardiolipin and lipid A. From the results of this study, we suggest that AMPR-11 is a new class of agent for overcoming low efficacy in the intravenous application of AMPs and is a promising candidate to overcome multidrug resistance. IMPORTANCE Abuse of antibiotics often leads to increase of multidrug-resistant (MDR) bacteria, which threatens the life of human beings. To overcome threat of antibiotic resistance, scientists are developing a novel class of antibiotics, antimicrobial peptides, that can eradicate MDR bacteria. Unfortunately, these antibiotics have mainly been developed to cure bacterial skin infections rather than others, such as life-threatening sepsis. Major pharmaceutical companies have tried to develop antiseptic drugs; however, they have not been successful. Here, we report that AMPR-11, the antimicrobial peptide (AMP) derived from mitochondrial nonselective channel Romo1, has antimicrobial activity against Gram-positive and Gram-negative bacteria comprising many clinically isolated MDR strains. Moreover, AMPR-11 increased the survival rate in a murine model of sepsis caused by MDR bacteria. We propose that AMPR-11 could be a novel antiseptic drug candidate with a broad antimicrobial spectrum to overcome MDR bacterial infection.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yoo, Young Do photo

Yoo, Young Do
College of Medicine (Department of Medical Science)
Read more

Altmetrics

Total Views & Downloads

BROWSE