Synergistic staphylocidal interaction of benzoic acid derivatives (benzoic acid, 4-hydroxybenzoic acid and beta-resorcylic acid) and capric acid: mechanism and verification study using artificial skin
DC Field | Value | Language |
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dc.contributor.author | Kim, H. W. | - |
dc.contributor.author | Seok, Y. S. | - |
dc.contributor.author | Rhee, M. S. | - |
dc.date.accessioned | 2021-08-31T08:49:43Z | - |
dc.date.available | 2021-08-31T08:49:43Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0305-7453 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/57488 | - |
dc.description.abstract | Objectives: The present study was designed to investigate a synergistic staphylocidal interaction of antimicrobials. Methods: The widely used preservative benzoic acid (BzA) and its derivatives [4-hydroxybenzoic acid (HA) and beta-resorcylic acid (beta-RA)] combined with capric acid (CPA) were investigated. Results: beta-RA was identified as the most effective antimicrobial exhibiting synergistic action with CPA against both Staphylococcus aureus and MRSA. For example, a complete reduction of bacteria (>7.3 log reduction) was obtained within 5 min after treatment with 5.0 mM beta-RA (0.079%) plus 0.20 mM CPA (0.004%), while treatment with each material individually showed low bactericidal effects (<1.5 log reduction). Flow cytometry analysis identified membrane disruption related to the synergistic mechanisms, including the following: (i) membrane disruption by CPA (69.2% of cells were damaged by 0.20 mM CPA treatment); (ii) antimicrobial entry through the damaged membrane; and (iii) cytoplasmic ion imbalance resulting in cell death. We verified that the synergistic combination was also effective against MRSA on artificial skin (99.989% elimination after 5 min). Conclusions: We used only consumer-preferred natural-borne antimicrobials and a very small amount of material was needed based on the synergistic effects. Therefore, these antimicrobials can be widely used as alternative anti-MRSA compounds in healthcare products, cosmetics, pharmaceutical products, foods and for environmental hygiene. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | CHAIN FATTY-ACIDS | - |
dc.subject | ESCHERICHIA-COLI | - |
dc.subject | ANTIBACTERIAL ACTIVITIES | - |
dc.subject | ORGANIC-ACIDS | - |
dc.subject | CARVACROL | - |
dc.subject | AUREUS | - |
dc.subject | THYMOL | - |
dc.subject | MODE | - |
dc.title | Synergistic staphylocidal interaction of benzoic acid derivatives (benzoic acid, 4-hydroxybenzoic acid and beta-resorcylic acid) and capric acid: mechanism and verification study using artificial skin | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rhee, M. S. | - |
dc.identifier.doi | 10.1093/jac/dkz494 | - |
dc.identifier.scopusid | 2-s2.0-85079344985 | - |
dc.identifier.wosid | 000518550200013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, v.75, no.3, pp.571 - 575 | - |
dc.relation.isPartOf | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | - |
dc.citation.title | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | - |
dc.citation.volume | 75 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 571 | - |
dc.citation.endPage | 575 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CHAIN FATTY-ACIDS | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | ANTIBACTERIAL ACTIVITIES | - |
dc.subject.keywordPlus | ORGANIC-ACIDS | - |
dc.subject.keywordPlus | CARVACROL | - |
dc.subject.keywordPlus | AUREUS | - |
dc.subject.keywordPlus | THYMOL | - |
dc.subject.keywordPlus | MODE | - |
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