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Evaluation of the protective efficacy of recombinant protective antigen vaccine (GC1109)-immunized human sera using passive immunization in a mouse model
- Authors
- Jo, Su Kyoung; Ahn, Bo-Eun; Choi, Eun Hye; Kang, Ji Eun; An, Hyonggin; Oh, Myoung-don; Rhie, Gi-eun
- Issue Date
- 11-2월-2020
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Anthrax vaccine; Passive immunization; Toxin neutralization assay; Survival rate
- Citation
- VACCINE, v.38, no.7, pp.1586 - 1588
- Indexed
- SCIE
SCOPUS
- Journal Title
- VACCINE
- Volume
- 38
- Number
- 7
- Start Page
- 1586
- End Page
- 1588
- ISSN
- 0264-410X
- Abstract
- The protective efficacy of human sera from vaccinated individuals with a new recombinant protective antigen anthrax vaccine (GC1109) against lethal spore challenge was evaluated in a mouse model. Eighteen human sera were selected from the vaccinated individuals based on their toxin neutralizing assay (TNA) titer (ED50 of 55 to 668). The selected sera were diluted and passively transferred to AB mice and the mice were subsequently challenged with 100 x LD50 of Bacillus anthracis Sterne spores. The correlation between the survival rate of passively immunized mice and the TNA ED50 of transferred sera was presented (r = 0.873, P-value < 0.001). The estimated TNA titer for 50% survival rate against lethal challenge was 197 (95% confidence interval of 149 and 260). The result suggest that GC1109 is protective against exposure to B. anthracis and the TNA titer of vaccinated serum can be an indicator for protective efficacy. (C) 2019 Elsevier Ltd. All rights reserved.
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