IL-33 changes CD25(hi) Tregs to Th17 cells through a dendritic cell-mediated pathway
DC Field | Value | Language |
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dc.contributor.author | Park, Su-Ho | - |
dc.contributor.author | Jung, Hak-Jun | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.accessioned | 2021-08-31T11:33:46Z | - |
dc.date.available | 2021-08-31T11:33:46Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/57859 | - |
dc.description.abstract | Interleukin (IL)-33 is an alarmin factor that is highly secreted in a variety of autoimmune diseases, induces maturation of dendritic cells (DCs) and differentiation of T helper 17 (Th17) cells. As the balance between Th17 cells and regulatory T cells (Tregs) is important to maintain immune homeostasis, in this study, we investigated the effects of IL-33 on Treg cell response. We observed that direct treatment with IL-33 had no effect on Treg differentiation, whereas IL-33-matured DCs (IL33-matDCs) inhibited the differentiation of CD4(+) T cells to Tregs by decreasing the expression of Foxp3. Furthermore, co-culture with IL-33-matDCs changed stable Tregs (CD25(hi)CD4(+) Tregs) to IL-17-producing cells, whereas IL-33-matDCs had little effects on unstable Tregs (CD25(lo)CD4(+) Tregs). The stable Tregs were demonstrated to express high levels of IL-6 receptors. Blocking of IL-6 secreted from IL-33-matDCs suppressed the conversion of Tregs to Th17 cells, indicating the greater propensity to convert stable Tregs to Th17 cells is due to IL-6 signaling. Taken together, these results demonstrate that IL-33 inhibits Treg differentiation and the conversion of stable Tregs to Th17 cells via DCs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | REGULATORY T-CELLS | - |
dc.subject | PLASTICITY | - |
dc.subject | EXPRESSION | - |
dc.subject | CONVERSION | - |
dc.subject | RESPONSES | - |
dc.subject | FOXP3 | - |
dc.subject | BAD | - |
dc.title | IL-33 changes CD25(hi) Tregs to Th17 cells through a dendritic cell-mediated pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1016/j.imlet.2019.12.003 | - |
dc.identifier.scopusid | 2-s2.0-85076717357 | - |
dc.identifier.wosid | 000510953000002 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGY LETTERS, v.218, pp.5 - 10 | - |
dc.relation.isPartOf | IMMUNOLOGY LETTERS | - |
dc.citation.title | IMMUNOLOGY LETTERS | - |
dc.citation.volume | 218 | - |
dc.citation.startPage | 5 | - |
dc.citation.endPage | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CONVERSION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | FOXP3 | - |
dc.subject.keywordPlus | BAD | - |
dc.subject.keywordAuthor | IL-33 | - |
dc.subject.keywordAuthor | Matured DCs | - |
dc.subject.keywordAuthor | Treg conversion | - |
dc.subject.keywordAuthor | Th17 cells | - |
dc.subject.keywordAuthor | Treg differentiation | - |
dc.subject.keywordAuthor | IL-6 signaling | - |
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