IL-33 changes CD25(hi) Tregs to Th17 cells through a dendritic cell-mediated pathway
- Authors
- Park, Su-Ho; Jung, Hak-Jun; Kim, Tae Sung
- Issue Date
- 2월-2020
- Publisher
- ELSEVIER
- Keywords
- IL-33; Matured DCs; Treg conversion; Th17 cells; Treg differentiation; IL-6 signaling
- Citation
- IMMUNOLOGY LETTERS, v.218, pp.5 - 10
- Indexed
- SCIE
SCOPUS
- Journal Title
- IMMUNOLOGY LETTERS
- Volume
- 218
- Start Page
- 5
- End Page
- 10
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/57859
- DOI
- 10.1016/j.imlet.2019.12.003
- ISSN
- 0165-2478
- Abstract
- Interleukin (IL)-33 is an alarmin factor that is highly secreted in a variety of autoimmune diseases, induces maturation of dendritic cells (DCs) and differentiation of T helper 17 (Th17) cells. As the balance between Th17 cells and regulatory T cells (Tregs) is important to maintain immune homeostasis, in this study, we investigated the effects of IL-33 on Treg cell response. We observed that direct treatment with IL-33 had no effect on Treg differentiation, whereas IL-33-matured DCs (IL33-matDCs) inhibited the differentiation of CD4(+) T cells to Tregs by decreasing the expression of Foxp3. Furthermore, co-culture with IL-33-matDCs changed stable Tregs (CD25(hi)CD4(+) Tregs) to IL-17-producing cells, whereas IL-33-matDCs had little effects on unstable Tregs (CD25(lo)CD4(+) Tregs). The stable Tregs were demonstrated to express high levels of IL-6 receptors. Blocking of IL-6 secreted from IL-33-matDCs suppressed the conversion of Tregs to Th17 cells, indicating the greater propensity to convert stable Tregs to Th17 cells is due to IL-6 signaling. Taken together, these results demonstrate that IL-33 inhibits Treg differentiation and the conversion of stable Tregs to Th17 cells via DCs.
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Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
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