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Differences in neuroimaging features of early-versus late-onset nonfluent/agrammatic primary progressive aphasia

Authors
Lee, Jin SanYoo, SolePark, SeongbeomKim, Hee JinPark, Key-ChungSeong, Joon-KyungSuh, Mee KyungLee, JuyounJang, HyeminKim, Ko WoonKim, YeshinCho, Soo HyunKim, Seung JooKim, Jun PyoJung, Young HeeKim, Eun-JooSuh, Yeon-LimLockhart, Samuel N.Seeley, William W.Na, Duk L.Seo, Sang Won
Issue Date
2월-2020
Publisher
ELSEVIER SCIENCE INC
Keywords
Frontotemporal dementia; Nonfluent/agrammatic variant of primary progressive aphasia; Age of symptom onset; Brain reserve hypothesis
Citation
NEUROBIOLOGY OF AGING, v.86, pp.92 - 101
Indexed
SCIE
SCOPUS
Journal Title
NEUROBIOLOGY OF AGING
Volume
86
Start Page
92
End Page
101
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/57876
DOI
10.1016/j.neurobiolaging.2019.10.011
ISSN
0197-4580
Abstract
This study investigated distinct neuroimaging features measured by cortical thickness and subcortical structural shape abnormality in early-onset (EO, onset age <65 years) and late-onset (LO, onset age >= 65 years) nonfluent/agrammatic variant of primary progressive aphasia (nfvPPA) patients. Cortical thickness and subcortical structural shape analyses were performed using a surface-based method from 38 patients with nfvPPA and 76 cognitively normal individuals. To minimize the effects of physiological aging, we used W-scores in comparisons between the groups. The EO-nfvPPA group exhibited more extensive cortical thickness reductions predominantly in the left perisylvian, lateral and medial prefrontal, temporal, posterior cingulate, and precuneus regions than the LO-nfvPPA group. The EO-nfvPPA group also exhibited significantly greater subcortical structural shape abnormality than the LO-nfvPPA group, mainly in the left striatum, hippocampus, and amygdala. Our findings suggested that there were differences in neuroimaging features between these groups by the age of symptom onset, which might be explained by underlying heterogeneous neuropathological differences or the age-related brain reserve hypothesis. (C) 2019 Elsevier Inc. All rights reserved.
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