Compartment-restricted and rate-controlled dual drug delivery system using a biosilica-enveloped ferritin cage
- Authors
- Ki, Mi-Ran; Kim, Jong Ki; Kim, Sung Ho; Thi Khoa My Nguyen; Kim, Kyung Hee; Pack, Seung Pil
- Issue Date
- 25-Jan-2020
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Ferritin; Biosilica encapsulation; Dual drug delivery system; Doxorubicin; Paclitaxel
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.81, pp 367 - 374
- Pages
- 8
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 81
- Start Page
- 367
- End Page
- 374
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/57953
- DOI
- 10.1016/j.jiec.2019.09.027
- ISSN
- 1226-086X
1876-794X
- Abstract
- Combinational therapy has been exploited to enhance therapeutic efficiency against cancer by overcoming drug resistance and side-effects or by synergistic effects of multi drugs. However, the conventional co-delivery of combination regimens is often limited by the differences in physicochemical properties among different drugs. Here, to solve this problem, we demonstrated an advanced dual drug delivery system (dDDS) using a R5 peptide-fused ferritin (R5FT). Since the fused R5 can mediate biosilica deposition on the ferritin surface (SiO2/R5FT), we could load two types of molecules into the core inside (ferritin cage) and the shell outside (biosilica matrix), respectively. Doxorubicin (Dox) was loaded into the cage by the reassembly of R5FT to obtain R5FT(Dox), and then the monomeric red fluorescent protein (mRFP) or paclitaxel (VEX) was captured in situ by biosilica matrix formation to prepare SiO2 (mRFP)/R5FT (Dox) or SiO2 (PTX)/R5FT(Dox). The captured mRFP or PTX in the shell exhibited a short-term release, while Dox in the core showed a long-term sustained release. This dDDS with the additional release of PTX decreased the IC50 value of Dox by twofold compared to the use of only Dox in dDDS. The compartment-restricted and rate-controlled dDDS using biosilica-enveloped ferritin cage can provide more efficient combinational drug therapies. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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- Appears in
Collections - College of Science and Technology > ETC > 1. Journal Articles
- Graduate School > Department of Biotechnology and Bioinformatics > 1. Journal Articles

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