Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy
DC Field | Value | Language |
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dc.contributor.author | Hada, Manila | - |
dc.contributor.author | Oh, Hannah | - |
dc.contributor.author | Fan, Shaoqi | - |
dc.contributor.author | Falk, Roni T. | - |
dc.contributor.author | Geller, Berta | - |
dc.contributor.author | Vacek, Pamela | - |
dc.contributor.author | Weaver, Donald | - |
dc.contributor.author | Shepherd, John | - |
dc.contributor.author | Wang, Jeff | - |
dc.contributor.author | Fan, Bo | - |
dc.contributor.author | Herschorn, Sally | - |
dc.contributor.author | Brinton, Louise A. | - |
dc.contributor.author | Xu, Xia | - |
dc.contributor.author | Sherman, Mark E. | - |
dc.contributor.author | Trabert, Britton | - |
dc.contributor.author | Gierach, Gretchen L. | - |
dc.date.accessioned | 2021-08-31T15:11:23Z | - |
dc.date.available | 2021-08-31T15:11:23Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/58542 | - |
dc.description.abstract | The association of progesterone/progesterone metabolites with elevated mammographic breast density (MBD) and delayed age-related terminal duct lobular unit (TDLU) involution, strong breast cancer risk factors, has received limited attention. Using a reliable liquid chromatography-tandem mass-spectrometry assay, we quantified serum progesterone/progesterone metabolites and explored cross-sectional relationships with MBD and TDLU involution among women, ages 40-65, undergoing diagnostic breast biopsy. Quantitative MBD measures were estimated in pre-biopsy digital mammograms. TDLU involution was quantified in diagnostic biopsies. Adjusted partial correlations and trends across MBD/TDLU categories were calculated. Pregnenolone was positively associated with percent MBD-area (MBD-A, rho: 0.30; p-trend = 0.01) among premenopausal luteal phase women. Progesterone tended to be positively associated with percent MBD-A among luteal phase (rho: 0.26; p-trend = 0.07) and postmenopausal (rho: 0.17; p-trend = 0.04) women. Consistent with experimental data, implicating an elevated 5 alpha-pregnanes/3 alpha-dihydroprogesterone (5 alpha P/3 alpha HP) metabolite ratio in breast cancer, higher 5 alpha P/3 alpha HP was associated with elevated percent MBD-A among luteal phase (rho: 0.29; p-trend = 0.08), but not postmenopausal women. This exploratory analysis provided some evidence that endogenous progesterone and progesterone metabolites might be correlated with MBD, a strong breast cancer risk factor, in both pre- and postmenopausal women undergoing breast biopsy. Additional studies are needed to understand the role of progesterone/progesterone metabolites in breast tissue composition and breast cancer risk. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | CIRCULATING SEX-HORMONES | - |
dc.subject | CANCER RISK | - |
dc.subject | ESTROGENS | - |
dc.subject | TISSUE | - |
dc.subject | ASSOCIATION | - |
dc.subject | MECHANISMS | - |
dc.subject | DISEASE | - |
dc.subject | VOLUME | - |
dc.title | Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Hannah | - |
dc.identifier.doi | 10.3390/jcm9010245 | - |
dc.identifier.wosid | 000515388400245 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.9, no.1 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CIRCULATING SEX-HORMONES | - |
dc.subject.keywordPlus | CANCER RISK | - |
dc.subject.keywordPlus | ESTROGENS | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordAuthor | mammographic density | - |
dc.subject.keywordAuthor | breast density | - |
dc.subject.keywordAuthor | progesterone | - |
dc.subject.keywordAuthor | serum progesterone assay | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.subject.keywordAuthor | liquid chromatography-tandem mass spectrometry | - |
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