Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy
- Authors
- Hada, Manila; Oh, Hannah; Fan, Shaoqi; Falk, Roni T.; Geller, Berta; Vacek, Pamela; Weaver, Donald; Shepherd, John; Wang, Jeff; Fan, Bo; Herschorn, Sally; Brinton, Louise A.; Xu, Xia; Sherman, Mark E.; Trabert, Britton; Gierach, Gretchen L.
- Issue Date
- 1월-2020
- Publisher
- MDPI
- Keywords
- mammographic density; breast density; progesterone; serum progesterone assay; breast cancer; liquid chromatography-tandem mass spectrometry
- Citation
- JOURNAL OF CLINICAL MEDICINE, v.9, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- Volume
- 9
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/58542
- DOI
- 10.3390/jcm9010245
- ISSN
- 2077-0383
- Abstract
- The association of progesterone/progesterone metabolites with elevated mammographic breast density (MBD) and delayed age-related terminal duct lobular unit (TDLU) involution, strong breast cancer risk factors, has received limited attention. Using a reliable liquid chromatography-tandem mass-spectrometry assay, we quantified serum progesterone/progesterone metabolites and explored cross-sectional relationships with MBD and TDLU involution among women, ages 40-65, undergoing diagnostic breast biopsy. Quantitative MBD measures were estimated in pre-biopsy digital mammograms. TDLU involution was quantified in diagnostic biopsies. Adjusted partial correlations and trends across MBD/TDLU categories were calculated. Pregnenolone was positively associated with percent MBD-area (MBD-A, rho: 0.30; p-trend = 0.01) among premenopausal luteal phase women. Progesterone tended to be positively associated with percent MBD-A among luteal phase (rho: 0.26; p-trend = 0.07) and postmenopausal (rho: 0.17; p-trend = 0.04) women. Consistent with experimental data, implicating an elevated 5 alpha-pregnanes/3 alpha-dihydroprogesterone (5 alpha P/3 alpha HP) metabolite ratio in breast cancer, higher 5 alpha P/3 alpha HP was associated with elevated percent MBD-A among luteal phase (rho: 0.29; p-trend = 0.08), but not postmenopausal women. This exploratory analysis provided some evidence that endogenous progesterone and progesterone metabolites might be correlated with MBD, a strong breast cancer risk factor, in both pre- and postmenopausal women undergoing breast biopsy. Additional studies are needed to understand the role of progesterone/progesterone metabolites in breast tissue composition and breast cancer risk.
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Collections - Graduate School > Department of Public Health Sciences > 1. Journal Articles
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