Assessment of Sex Differences in 5-Year Clinical Outcomes Following Endovascular Revascularization for Peripheral Artery Disease
- Authors
- Lee, Michael S.; Choi, Byoung Geol; Hollowed, John; Han, Seung Kyu; Baek, Man Jong; Ryue, Yang Gi; Choi, Se Yeon; Byun, Jae Kyeong; Mashaly, Ahmed; Park, Yoonjee; Jang, Won Young; Kimc, Woohyeun; Choi, Jah Yeon; Park, Eun Jin; Na, Jin Oh.; Choi, Cheol Ung; Kim, Eung Ju; Park, Chang Gyu; Seo, Hong Seog; Rha, Seung-Woon
- Issue Date
- 1월-2020
- Publisher
- ELSEVIER INC
- Keywords
- Peripheral artery disease; Critical limb ischemia; Percutaneous transluminal angioplasty; Endovascular therapy; Sex; Clinical outcomes
- Citation
- CARDIOVASCULAR REVASCULARIZATION MEDICINE, v.21, no.1, pp.110 - 115
- Indexed
- SCOPUS
- Journal Title
- CARDIOVASCULAR REVASCULARIZATION MEDICINE
- Volume
- 21
- Number
- 1
- Start Page
- 110
- End Page
- 115
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/58557
- DOI
- 10.1016/j.carrev.2019.03.018
- ISSN
- 1553-8389
- Abstract
- Percutaneous transluminal angioplasty (PTA) is an effective treatment strategy for peripheral artery disease (PAD). Data are limiting regarding sex differences in patients with PAD who underwent PTA. We assessed the sex-related differences on 5-year clinical outcomes in patients with PAD who underwent PTA. We prospectively evaluated 765 patients with PAD (596 males and 169 females) who underwent PTA. We performed propensity score matching (PSM) analysis to adjust for any potential confounders. The primary endpoints were 5-year major adverse cardiac and cerebrovascular events (MACE) and major adverse lower-limb events (MALE) assessed by Kaplan-Meier curved analysis and log rank test. After PSM analysis, baseline clinical characteristics were similar in male and female patients. There was a trend toward a higher rate of major hematoma in female patients (6.1% vs. 0.9%, p= 0.066) and a lower rate of below the ankle amputation (24.7% vs. 16.5%, p= 0.097). During the 5-year clinical follow-up, male and female patients had similar rates of MACE (14.9% vs. 15.8%, log rank p= 0.838) and MALE (34.8% vs. 28.2%, log rank p= 0.264) aswell as the individual endpoints. In subgroup analysis adjusted by PSM, female patients had a higher risk of bleeding complications in age >= 65 years, hypertension, diabetes mellitus, chronic kidney disease, and in the non-critical limb ischemia patients. Of patients with preserved renal function, female patients had a higher risk of MALE as compared tomales. In conclusion, female patients with PAD who underwent PTA showed similar 5-year MACE and MALE compared with male patients. (C) 2019 Published by Elsevier Inc.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.