Performance comparison of platelet function analyzers in cardiology patients: VerifyNow and Anysis-200 aspirin assays
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Young Hak | - |
dc.contributor.author | Lee, Kyung Ah | - |
dc.contributor.author | Cho, Minhee | - |
dc.contributor.author | Shin, Sehyun | - |
dc.contributor.author | Lee, Byoung Kwon | - |
dc.date.accessioned | 2021-08-31T16:12:05Z | - |
dc.date.available | 2021-08-31T16:12:05Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1386-0291 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/59044 | - |
dc.description.abstract | BACKGROUND: Analysis of responsiveness to antiplatelet therapy is crucial in the management of patients with cardiovascular diseases. OBJECTIVE: This study aimed to evaluate a new platelet function analysis system (Anysis-200) and to compare it with VerifyNow (Accumetrics, San Diego, CA, USA) in cardiology patients. METHODS: Overall, 125 citrated blood samples were collected from 85 cardiology patients referred for platelet function testing. In Anysis-200, platelet function was measured as blood migration distance (MD) until clogging of flow passage, which is comparable to aspirin resistance units obtained using VerifyNow. The two devices were simultaneously used and compared. RESULTS: The MDs before and after taking aspirin were 175 +/- 51 and 247 +/- 27 mm, respectively (p < 0.0001). Compared with VerifyNow (reference), the sensitivity and specificity of Anysis-200 was 91.5% and 75.5%, respectively (area under the curve, 0.829). Further, the true positive rate in patients newly taking aspirin was 85% for VerifyNow and 92.5% for Anysis-200, respectively. The Cohen's kappa coefficient between the two devices was 0.682, indicating a relatively high agreement. CONCLUSIONS: Anysis-200, a novel system for assessing platelet aggregation, has accuracy and precision equivalent to that of, and significant agreement with, VerifyNow. Anysis-200 may be useful in screening patients with abnormal platelet reactivity and aspirin nonresponsiveness. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IOS PRESS | - |
dc.subject | REACTIVITY | - |
dc.subject | CLOPIDOGREL | - |
dc.subject | CONSENSUS | - |
dc.subject | DEFINITION | - |
dc.subject | THERAPY | - |
dc.subject | UPDATE | - |
dc.subject | IMPACT | - |
dc.title | Performance comparison of platelet function analyzers in cardiology patients: VerifyNow and Anysis-200 aspirin assays | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Sehyun | - |
dc.identifier.doi | 10.3233/CH-200822 | - |
dc.identifier.scopusid | 2-s2.0-85088318833 | - |
dc.identifier.wosid | 000582722500004 | - |
dc.identifier.bibliographicCitation | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, v.76, no.1, pp.33 - 42 | - |
dc.relation.isPartOf | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | - |
dc.citation.title | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | - |
dc.citation.volume | 76 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.citation.endPage | 42 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | REACTIVITY | - |
dc.subject.keywordPlus | CLOPIDOGREL | - |
dc.subject.keywordPlus | CONSENSUS | - |
dc.subject.keywordPlus | DEFINITION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | UPDATE | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordAuthor | Platelet function | - |
dc.subject.keywordAuthor | aspirin | - |
dc.subject.keywordAuthor | Anysis-200 analyzer | - |
dc.subject.keywordAuthor | VerifyNow | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.