Efficacy and Safety of Nebivolol and Rosuvastatin Combination Treatment in Patients with Concomitant Hypertension and Hyperlipidemia
- Authors
- Rhee, Moo-Yong; Kim, Cheol Ho; Ahn, Youngkeun; Shin, Joon-Han; Han, Seung Hwan; Kang, Hyun-Jae; Hong, Soon Jun; Kim, Hae-Young
- Issue Date
- 2020
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- hypertension; hypercholesterolemia; nebivolol; rosuvastatin
- Citation
- DRUG DESIGN DEVELOPMENT AND THERAPY, v.14, pp.5005 - 5017
- Indexed
- SCIE
SCOPUS
- Journal Title
- DRUG DESIGN DEVELOPMENT AND THERAPY
- Volume
- 14
- Start Page
- 5005
- End Page
- 5017
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/59063
- DOI
- 10.2147/DDDT.S280055
- ISSN
- 1177-8881
- Abstract
- Purpose: We evaluated the efficacy and safety of nebivolol and rosuvastatin combination treatment in patients with hypertension and hyperlipidemia. Patients and Methods: Eligible patients, after more than 4 weeks of therapeutic lifestyle change, were randomly assigned to three groups: 5 mg nebivolol plus 20 mg rosuvastatin (NEBI/RSV), 20 mg rosuvastatin (RSV), or 5 mg nebivolol (NEBI). Treatments lasted 8 weeks. Results: Efficacy was analyzed using data from 276 patients. Sitting systolic and diastolic blood pressures differed between the NEBI/RSV and RSV groups (LSmean difference = -5.89 and -5.99 mmHg; 95% confidence interval [CI] = -9.88 to -1.90 mmHg and -8.13 to -3.84 mmHg, respectively). Reductions in the two pressures did not differ between the NEB/RSV and NEB groups. The percent reduction in low-density lipoprotein (LDL) cholesterol differed between the NEBI/RSV and NEBI groups (LSmean difference = -47.76%, 95% CI = -52.69 to -42.84%) but not between the NEBI/RSV and RSV groups. The blood pressure (BP) control rate was higher in the NEBI/RSV group than in the RVS group (51.09% vs 29.67%, p = 0.003). The LDL cholesterol goal achievement rate was higher in the NEBI/RSV group than in the NEBI group (85.87% vs 11.83%, p < 0.001). The incidence of adverse drug reactions in the NEBI/RSV, RSV, and NEBI groups was 8.51%, 7.45%, and 8.60%, respectively (p = 0.950). Conclusion: Nebivolol plus rosuvastatin treatment is effective in reducing BP and LDL cholesterol levels and is safe in patients with hypertension and hypercholesterolemia without the loss of BP or the LDL cholesterol-lowering effect of each drug.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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