PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances
DC Field | Value | Language |
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dc.contributor.author | Shin, Sang-Woo | - |
dc.contributor.author | Jang, Yeon-Do | - |
dc.contributor.author | Ko, Kyoung-Won | - |
dc.contributor.author | Kang, Eun Young | - |
dc.contributor.author | Han, Jun-Hyeok | - |
dc.contributor.author | Bedair, Tarek M. | - |
dc.contributor.author | Kim, Ik-Hwan | - |
dc.contributor.author | Son, Tae -Il | - |
dc.contributor.author | Park, Wooram | - |
dc.contributor.author | Han, Dong Keun | - |
dc.date.accessioned | 2021-08-31T19:40:37Z | - |
dc.date.available | 2021-08-31T19:40:37Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-12-25 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/60875 | - |
dc.description.abstract | Polymeric microspheres containing magnesium hydroxide (MH) was developed as a functional dermal filler with enhanced physicochemical and biological performances. In this study, polycaprolactone (PCL) and MH microspheres (PCL/MH) were uniformly produced with approximately 50 mu m in size through a simple fluidic device. In the PCL/MH composite, MH effectively neutralized the acidic degradation products generated by polymer degradation. In in vitro cell experiments, when MH was treated with acidic decomposition product (i.e., 6-hydroxycaproic acid, HCA), the acidic pH was neutralized to induce wound healing along with inhibition of inflammation and senescence. Furthermore, MH promoted the production of collagen. These results suggest that the PCL/MH microspheres have great potential as a functional dermal filler for skin esthetics and facial plastic surgery. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | DECELLULARIZED EXTRACELLULAR-MATRIX | - |
dc.subject | SIMPLE FLUIDIC DEVICE | - |
dc.subject | HYALURONIC-ACID | - |
dc.subject | DEGRADATION | - |
dc.subject | FABRICATION | - |
dc.subject | HYDROGELS | - |
dc.title | PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Ik-Hwan | - |
dc.identifier.doi | 10.1016/j.jiec.2019.07.043 | - |
dc.identifier.scopusid | 2-s2.0-85070531820 | - |
dc.identifier.wosid | 000501658800096 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.80, pp.854 - 861 | - |
dc.relation.isPartOf | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 80 | - |
dc.citation.startPage | 854 | - |
dc.citation.endPage | 861 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002542464 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | DECELLULARIZED EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | SIMPLE FLUIDIC DEVICE | - |
dc.subject.keywordPlus | HYALURONIC-ACID | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordAuthor | Dermal filler | - |
dc.subject.keywordAuthor | Polycaprolactone (PCL) microspheres | - |
dc.subject.keywordAuthor | Magnesium hydroxide (MH) | - |
dc.subject.keywordAuthor | Anti-inflammation | - |
dc.subject.keywordAuthor | Anti-senescence | - |
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