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PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances

Authors
Shin, Sang-WooJang, Yeon-DoKo, Kyoung-WonKang, Eun YoungHan, Jun-HyeokBedair, Tarek M.Kim, Ik-HwanSon, Tae -IlPark, WooramHan, Dong Keun
Issue Date
25-12월-2019
Publisher
ELSEVIER SCIENCE INC
Keywords
Dermal filler; Polycaprolactone (PCL) microspheres; Magnesium hydroxide (MH); Anti-inflammation; Anti-senescence
Citation
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.80, pp.854 - 861
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume
80
Start Page
854
End Page
861
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/60875
DOI
10.1016/j.jiec.2019.07.043
ISSN
1226-086X
Abstract
Polymeric microspheres containing magnesium hydroxide (MH) was developed as a functional dermal filler with enhanced physicochemical and biological performances. In this study, polycaprolactone (PCL) and MH microspheres (PCL/MH) were uniformly produced with approximately 50 mu m in size through a simple fluidic device. In the PCL/MH composite, MH effectively neutralized the acidic degradation products generated by polymer degradation. In in vitro cell experiments, when MH was treated with acidic decomposition product (i.e., 6-hydroxycaproic acid, HCA), the acidic pH was neutralized to induce wound healing along with inhibition of inflammation and senescence. Furthermore, MH promoted the production of collagen. These results suggest that the PCL/MH microspheres have great potential as a functional dermal filler for skin esthetics and facial plastic surgery. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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