Ultrafast Chemical Exchange Dynamics of Hydrogen Bonds Observed via Isonitrile Infrared Sensors: Implications for Biomolecular Studies
DC Field | Value | Language |
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dc.contributor.author | Kubel, Joachim | - |
dc.contributor.author | Lee, Giseong | - |
dc.contributor.author | Ooi, Saik Ann | - |
dc.contributor.author | Westenhoff, Sebastian | - |
dc.contributor.author | Han, Hogyu | - |
dc.contributor.author | Cho, Minhaeng | - |
dc.contributor.author | Maj, Michal | - |
dc.date.accessioned | 2021-08-31T20:02:20Z | - |
dc.date.available | 2021-08-31T20:02:20Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-12-19 | - |
dc.identifier.issn | 1948-7185 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/60897 | - |
dc.description.abstract | Local probes are indispensable to study protein structure and dynamics with site-specificity. The isonitrile functional group is a highly sensitive and H-bonding interaction-specific probe. Isonitriles exhibit large spectral shifts and transition dipole moment changes upon H-bonding while being weakly affected by solvent polarity. These unique properties allow a clear separation of distinct subpopulations of interacting species and an elucidation of their ultrafast dynamics with two-dimensional infrared (2D-IR) spectroscopy. Here, we apply 2D-IR to quantify the picosecond chemical exchange dynamics of solute solvent complexes forming between isonitrile-derivatized alanine and fluorinated ethanol, where the degree of fluorination controls their H-bond-donating ability. We show that the molecules undergo faster exchange in the presence of more acidic H-bond donors, indicating that the exchange process is primarily dependent on the nature of solvent-solvent interactions. We foresee isonitrile as a highly promising probe for studying of H-bonds dynamics in the active site of enzymes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | 2D IR SPECTROSCOPY | - |
dc.subject | 2D-IR SPECTROSCOPY | - |
dc.subject | JUMP MECHANISM | - |
dc.subject | PROBES | - |
dc.subject | SOLVATOCHROMISM | - |
dc.subject | SURFACE | - |
dc.title | Ultrafast Chemical Exchange Dynamics of Hydrogen Bonds Observed via Isonitrile Infrared Sensors: Implications for Biomolecular Studies | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Hogyu | - |
dc.identifier.doi | 10.1021/acs.jpclett.9b03144 | - |
dc.identifier.scopusid | 2-s2.0-85076560007 | - |
dc.identifier.wosid | 000503919300050 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHYSICAL CHEMISTRY LETTERS, v.10, no.24, pp.7878 - 7883 | - |
dc.relation.isPartOf | JOURNAL OF PHYSICAL CHEMISTRY LETTERS | - |
dc.citation.title | JOURNAL OF PHYSICAL CHEMISTRY LETTERS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 7878 | - |
dc.citation.endPage | 7883 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Atomic, Molecular & Chemical | - |
dc.subject.keywordPlus | 2D IR SPECTROSCOPY | - |
dc.subject.keywordPlus | 2D-IR SPECTROSCOPY | - |
dc.subject.keywordPlus | JUMP MECHANISM | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | SOLVATOCHROMISM | - |
dc.subject.keywordPlus | SURFACE | - |
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