SERS-based particle tracking and molecular imaging in live cells: toward the monitoring of intracellular dynamics
- Authors
- Kim, Jongwoo; Nam, Sang Hwan; Lim, Dong-Kwon; Suh, Yung Doug
- Issue Date
- 7-12월-2019
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- NANOSCALE, v.11, no.45, pp.21724 - 21727
- Indexed
- SCIE
SCOPUS
- Journal Title
- NANOSCALE
- Volume
- 11
- Number
- 45
- Start Page
- 21724
- End Page
- 21727
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/60941
- DOI
- 10.1039/c9nr05159g
- ISSN
- 2040-3364
- Abstract
- Although diverse endogenous biomolecules involved in life processes are of major interest in cell biology, there is still a lack of suitable methods for studying biomolecules within live cells without labelling. Herein, we describe a near-infrared (NIR) surface-enhanced Raman scattering (SERS)-based particle tracking technique gathering chemical information inside live cells for monitoring their intracellular dynamics. The wide-field SERS imaging spectroscopy system facilitates high temporal resolution (200 ms) under high spatial resolution (512 x 512 pixels) for one live cell. With high spatiotemporal resolution and signal-to-background ratio, we show that the Raman signal from intracellular cargoes in live cells is sporadically observed and localized to a vesicular level.
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Collections - Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles
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