Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Chemical Constituents of the Leaves of Butterbur (Petasites japonicus) and Their Anti-Inflammatory Effects
- Authors
- Lee, Jin Su; Jeong, Miran; Park, Sangsu; Ryu, Seung Mok; Lee, Jun; Song, Ziteng; Guo, Yuanqiang; Choi, Jung-Hye; Lee, Dongho; Jang, Dae Sik
- Issue Date
- 12월-2019
- Publisher
- MDPI
- Keywords
- Petasites japonicus; Asteraceae; lignan; anti-inflammation; NO; PGE(2); iNOS; COX-2; molecular docking
- Citation
- BIOMOLECULES, v.9, no.12
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMOLECULES
- Volume
- 9
- Number
- 12
- ISSN
- 2218-273X
- Abstract
- Two new aryltetralin lactone lignans, petasitesins A and B were isolated from the hot water extract of the leaves of butterbur (Petasites japonicus) along with six known compounds. The chemical structures of lignans 1 and 2 were elucidated on the basis of 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Petasitesin A and cimicifugic acid D showed significant inhibitory effects on the production of both prostaglandin E2 (PGE(2)) and NO in RAW264.7 macrophages. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by compound 1 in RAW264.7 cells. Furthermore, compounds 1 and 3 exhibited strong affinities with both iNOS and COX-2 enzymes in molecular docking studies.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.