The Pseudomonas aeruginosa HSP70-like protein DnaK induces IL-1 beta expression via TLR4-dependent activation of the NF-kappa B and JNK signaling pathways
DC Field | Value | Language |
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dc.contributor.author | Lee, Jung-Hoon | - |
dc.contributor.author | Jeon, Jisu | - |
dc.contributor.author | Bai, Fang | - |
dc.contributor.author | Jin, Shouguang | - |
dc.contributor.author | Wu, Weihui | - |
dc.contributor.author | Ha, Un-Hwan | - |
dc.date.accessioned | 2021-08-31T22:35:08Z | - |
dc.date.available | 2021-08-31T22:35:08Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 0147-9571 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/61306 | - |
dc.description.abstract | IL-1 beta expression is increased in response to P. aeruginosa infection, but the responsible proteins have not been clearly elucidated. Here, we demonstrate for the first time that IL-1 beta expression is induced in response to the heat shock protein 70-like protein DnaK. Treatment with recombinant DnaK (rDnaK) increased IL-1 beta expression in a dose- and time-dependent manner, and the release of mature IL-1 beta in response to rDnaK was detected to an extent similar to that stimulated by the well-known agonists, lipopolysaccharide and nigericin. rDnaK-mediated IL-1 beta expression was driven by the NF-kappa B signaling pathway. In addition, expression was controlled by the JNK signaling pathway, although these two signaling cascades act independently upon rDnaK stimulation. Finally, rDnaK-induced IL-1 beta expression was initiated via the action of TLR4. Taken together, the data reveal that P. aeruginosa-derived DnaK induces expression of IL-1 beta via TLR4-dependent activation of the NF-kappa B and JNK signaling pathways. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | EXTRACELLULAR HSP70 | - |
dc.subject | CYTOKINE RESPONSES | - |
dc.subject | DUAL ROLE | - |
dc.subject | RECOGNITION | - |
dc.subject | RECEPTORS | - |
dc.subject | INFECTION | - |
dc.subject | INFLAMMASOME | - |
dc.subject | RESISTANCE | - |
dc.subject | CHAPERONE | - |
dc.subject | CELLS | - |
dc.title | The Pseudomonas aeruginosa HSP70-like protein DnaK induces IL-1 beta expression via TLR4-dependent activation of the NF-kappa B and JNK signaling pathways | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ha, Un-Hwan | - |
dc.identifier.doi | 10.1016/j.cimid.2019.101373 | - |
dc.identifier.scopusid | 2-s2.0-85074423816 | - |
dc.identifier.wosid | 000499096400019 | - |
dc.identifier.bibliographicCitation | COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, v.67 | - |
dc.relation.isPartOf | COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | - |
dc.citation.title | COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | - |
dc.citation.volume | 67 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.subject.keywordPlus | EXTRACELLULAR HSP70 | - |
dc.subject.keywordPlus | CYTOKINE RESPONSES | - |
dc.subject.keywordPlus | DUAL ROLE | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | INFLAMMASOME | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | CHAPERONE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | DnaK | - |
dc.subject.keywordAuthor | IL-1 beta | - |
dc.subject.keywordAuthor | JNK | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | Pseudomonas aeruginosa | - |
dc.subject.keywordAuthor | TLR4 | - |
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