Red ginseng extract regulates differentiation of monocytes to macrophage and inflammatory signalings in human monocytes
DC Field | Value | Language |
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dc.contributor.author | Kang, Bobin | - |
dc.contributor.author | Kim, Chae Young | - |
dc.contributor.author | Hwang, Jisu | - |
dc.contributor.author | Sun, Sojung | - |
dc.contributor.author | Yang, Hyunwon | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Choi, Hyeon-Son | - |
dc.date.accessioned | 2021-08-31T22:39:02Z | - |
dc.date.available | 2021-08-31T22:39:02Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/61344 | - |
dc.description.abstract | This study was aimed to investigate the effect of red ginseng extract (RGE) on monocyte to macrophage differentiation and inflammatory signalings in THP-1 human monocytes. In HPLC analysis, RGE contained saponin level of 516 mu g/mg (extract) with 14 ginsenosides. RGE effectively suppressed the monocyte-to-macrophage differentiation induced by phorbol 12-myristate 13-acetated (PMA) by inhibiting the THP-1 cell adhesion. This result is evidenced by the down-regulation of cluster of differentiation molecule beta (CD11 beta) and CD36. RGE significantly reduced translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) (78%), while cytosolic NF-kappa B was increased (53%), compared with LPS group. In addition, RGE significantly increased the protein abundance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and its target protein, hemoxygenase-1 (HO-1), but, Kelch-like ECH-associated protein 1 (KEAP1), a negative regulator of Nrf2, was greatly decreased by RGE. Furthermore, RGE effectively mediated the regulation of Nrf2 level in nucleus and cytoplasm of THP-1. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST | - |
dc.subject | FACTOR-KAPPA-B | - |
dc.subject | RAW264.7 CELLS | - |
dc.subject | NRF2 | - |
dc.subject | PROTECTS | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | INHIBITION | - |
dc.subject | ACTIVATION | - |
dc.subject | RESPONSES | - |
dc.subject | RB1 | - |
dc.title | Red ginseng extract regulates differentiation of monocytes to macrophage and inflammatory signalings in human monocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1007/s10068-019-00611-x | - |
dc.identifier.scopusid | 2-s2.0-85071421746 | - |
dc.identifier.wosid | 000496753800024 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.28, no.6, pp.1819 - 1828 | - |
dc.relation.isPartOf | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 28 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1819 | - |
dc.citation.endPage | 1828 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002532988 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | RAW264.7 CELLS | - |
dc.subject.keywordPlus | NRF2 | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | RB1 | - |
dc.subject.keywordAuthor | Human monocyte (THP-1) | - |
dc.subject.keywordAuthor | Red ginseng extract (RGE) | - |
dc.subject.keywordAuthor | Monocyte-to-macrophage differentiation | - |
dc.subject.keywordAuthor | Inflammatory signaling | - |
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